spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 14 Sep 2005
doi: 10.1242/dev.02037

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02037v1
132/20/4497    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klein, C.
Right arrow Articles by Fishell, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klein, C.
Right arrow Articles by Fishell, G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Cerebellum- and forebrain-derived stem cells possess intrinsic regional character


Corinna Klein, Simon J.B. Butt, Robert P. Machold, Jane E. Johnson, and Gord Fishell*
* Author for correspondence (e-mail: fishell{at}saturn.med.nyu.edu)

The existence of stem cells in the adult nervous system is well recognized; however, the potential of these cells is still widely debated. We demonstrate that neural stem cells exist within the embryonic and adult cerebellum. Comparing the potential of neural stem cells derived from the forebrain and cerebellum, we find that progeny derived from each of these brain regions retain regional character in vitro as well as after homotopic transplantation. However, when ectopically transplanted, neurosphere-derived cells from either region are largely unable to generate neurons. With regard specifically to embryonic and adult cerebellar stem cells, we observe that they are able to give rise to neurons that resemble different select classes of cerebellar subclasses when grafted into the perinatal host cerebellum. Most notably, upon transplantation to the perinatal cerebellum, cerebellar stem cells from all ages are able to acquire the position and mature electrophysiological properties of cerebellar granule cells.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
K. Leto, A. Bartolini, Y. Yanagawa, K. Obata, L. Magrassi, K. Schilling, and F. Rossi
Laminar Fate and Phenotype Specification of Cerebellar GABAergic Interneurons
J. Neurosci., May 27, 2009; 29(21): 7079 - 7091.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J. D. Kessler, H. Hasegawa, S. N. Brun, B. A. Emmenegger, Z.-J. Yang, J. W. Dutton, F. Wang, and R. J. Wechsler-Reya
N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma
Genes & Dev., January 15, 2009; 23(2): 157 - 170.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
B. Carletti and F. Rossi
Neurogenesis in the Cerebellum
Neuroscientist, February 1, 2008; 14(1): 91 - 100.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
K. Leto, B. Carletti, I. M. Williams, L. Magrassi, and F. Rossi
Different Types of Cerebellar GABAergic Interneurons Originate from a Common Pool of Multipotent Progenitor Cells.
J. Neurosci., November 8, 2006; 26(45): 11682 - 11694.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005