spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 15 Mar 2006
doi: 10.1242/dev.02318

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02318v1
133/8/1467    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shapiro, R. S.
Right arrow Articles by Anderson, K. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shapiro, R. S.
Right arrow Articles by Anderson, K. V.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Drosophila Ik2, a member of the I{kappa}B kinase family, is required for mRNA localization during oogenesis


Risa S. Shapiro and Kathryn V. Anderson*
* Author for correspondence (e-mail: k-anderson{at}ski.mskcc.org)

In both Drosophila and mammals, I{kappa}B kinases (IKKs) regulate the activity of Rel/NF-{kappa}B transcription factors by targeting their inhibitory partner proteins, I{kappa}Bs, for degradation. We identified mutations in ik2, the gene that encodes one of two Drosophila IKKs, and found that the gene is essential for viability. During oogenesis, ik2 is required in an NF-{kappa}B-independent process that is essential for the localization of oskar and gurken mRNAs; as a result, females that lack ik2 in the germline produce embryos that are both bicaudal and ventralized. The abnormal RNA localization in ik2 mutant oocytes can be attributed to defects in the organization of microtubule minus-ends. In addition, both mutant oocytes and mutant escaper adults have abnormalities in the organization of the actin cytoskeleton. These data suggest that this I{kappa}B kinase has an NF-{kappa}B-independent role in mRNA localization and helps to link microtubule minus-ends to the oocyte cortex, a novel function of the IKK family.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
A. Koto, E. Kuranaga, and M. Miura
Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development
J. Cell Biol., October 19, 2009; 187(2): 219 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-H. Lee, L. Y. Jan, and Y.-N. Jan
Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis
PNAS, April 14, 2009; 106(15): 6363 - 6368.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
Y. Song, L. Fee, T. H. Lee, and R. P. Wharton
The Molecular Chaperone Hsp90 Is Required for mRNA Localization in Drosophila melanogaster Embryos
Genetics, August 1, 2007; 176(4): 2213 - 2222.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
U. Abdu, D. Bar, and T. Schupbach
spn-F encodes a novel protein that affects oocyte patterning and bristle morphology in Drosophila
Development, April 15, 2006; 133(8): 1477 - 1484.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006