spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 3 May 2006
doi: 10.1242/dev.02386

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02386v1
133/11/2177    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gupta, S.
Right arrow Articles by Evans, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gupta, S.
Right arrow Articles by Evans, T.

Research article

BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis


Sunny Gupta, Hao Zhu, Leonard I. Zon, and Todd Evans*
* Author for correspondence (e-mail: tevans{at}aecom.yu.edu)

The bone morphogenetic protein (BMP) signaling pathway is essential during gastrulation for the generation of ventral mesoderm, which makes it a challenge to define functions for this pathway at later stages of development. We have established an approach to disrupt BMP signaling specifically in lateral mesoderm during somitogenesis, by targeting a dominant-negative BMP receptor to Lmo2+ cells in developing zebrafish embryos. This results in expansion of hematopoietic and endothelial cells, while restricting the expression domain of the pronephric marker pax2.1. Expression of a constitutively active receptor and transplantation experiments were used to confirm that BMP signaling in lateral mesoderm restricts subsequent hemato-vascular development. The results show that the BMP signaling pathway continues to function after cells are committed to a lateral mesoderm fate, and influences subsequent lineage decisions by restricting hemato-vascular fate in favor of pronephric development.


This article has been cited by other articles:


Home page
 DevelopmentHome page
S. P. Mudumana, D. Hentschel, Y. Liu, A. Vasilyev, and I. A. Drummond
odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate
Development, October 15, 2008; 135(20): 3355 - 3367.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Zhang, X.-T. Bai, K.-Y. Zhu, Y. Jin, M. Deng, H.-Y. Le, Y.-F. Fu, Y. Chen, J. Zhu, A. T. Look, et al.
In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury
J. Immunol., August 1, 2008; 181(3): 2155 - 2164.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-Y. Le, Y. Zhang, H. Liu, L.-H. Ma, Y. Jin, Q.-H. Huang, Y. Chen, M. Deng, Z. Chen, S.-J. Chen, et al.
eena Promotes Myeloid Proliferation through Stimulating ERK1/2 Phosphorylation in Zebrafish
J. Biol. Chem., June 20, 2008; 283(25): 17652 - 17661.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
F. Lohmann and J. J. Bieker
Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment
Development, June 15, 2008; 135(12): 2071 - 2082.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. J. McReynolds, S. Gupta, M. E. Figueroa, M. C. Mullins, and T. Evans
Smad1 and Smad5 differentially regulate embryonic hematopoiesis
Blood, December 1, 2007; 110(12): 3881 - 3890.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. E. Pimanda, I. J. Donaldson, M. F. T. R. de Bruijn, S. Kinston, K. Knezevic, L. Huckle, S. Piltz, J.-R. Landry, A. R. Green, D. Tannahill, et al.
The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity
PNAS, January 16, 2007; 104(3): 840 - 845.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. T. Naito, I. Shiojima, H. Akazawa, K. Hidaka, T. Morisaki, A. Kikuchi, and I. Komuro
Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis
PNAS, December 26, 2006; 103(52): 19812 - 19817.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006