spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 21 Jun 2006
doi: 10.1242/dev.02477

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02477v1
133/15/2875    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kellerer, S.
Right arrow Articles by Wegner, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kellerer, S.
Right arrow Articles by Wegner, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article

Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence


Susanne Kellerer, Silke Schreiner, C. Claus Stolt, Stefanie Scholz, Michael R. Bösl, and Michael Wegner*
* Author for correspondence (e-mail: m.wegner{at}biochem.uni-erlangen.de)

Sox8 and Sox10 are two closely related transcription factors of the Sox protein family with overlapping expression patterns during development. They are believed to perform very similar functions because several developmental processes, including enteric nervous system development and oligodendrocyte differentiation, are regulated by both Sox proteins. To analyze the extent of functional equivalence between the two Sox proteins, we employed targeted mutagenesis to replace Sox10 with Sox8 in the mouse. In mice that expressed Sox8 instead of Sox10, Sox10 deficiency was phenotypically rescued to different extents in affected tissues. Whereas development of glial cells and neurons in the sensory and sympathetic parts of the peripheral nervous system was almost normal when Sox10 was replaced by Sox8, melanocyte development was as defective as in Sox10-deficient mice. The ability of Sox8 to rescue the defects in enteric nervous system development and oligodendrocyte differentiation of Sox10-deficient mice was limited. We conclude that the extent of functional equivalence depends on the tissue and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Lipid Res.Home page
S. I. E. Guth, K. Schmidt, A. Hess, and M. Wegner
Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor
J. Lipid Res., July 1, 2009; 50(7): 1269 - 1280.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Hoser, M. R. Potzner, J. M. C. Koch, M. R. Bosl, M. Wegner, and E. Sock
Sox12 Deletion in the Mouse Reveals Nonreciprocal Redundancy with the Related Sox4 and Sox11 Transcription Factors
Mol. Cell. Biol., August 1, 2008; 28(15): 4675 - 4687.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
S. Reiprich, C. C. Stolt, S. Schreiner, R. Parlato, and M. Wegner
SoxE Proteins Are Differentially Required in Mouse Adrenal Gland Development
Mol. Biol. Cell, April 1, 2008; 19(4): 1575 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
T. Werner, A. Hammer, M. Wahlbuhl, M. R. Bosl, and M. Wegner
Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis
Nucleic Acids Res., October 8, 2007; 35(19): 6526 - 6538.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Schreiner, F. Cossais, K. Fischer, S. Scholz, M. R. Bosl, B. Holtmann, M. Sendtner, and M. Wegner
Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages
Development, September 15, 2007; 134(18): 3271 - 3281.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. O'Donnell, C.-S. Hong, X. Huang, R. J. Delnicki, and J.-P. Saint-Jeannet
Functional analysis of Sox8 during neural crest development in Xenopus
Development, October 1, 2006; 133(19): 3817 - 3826.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006