spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 3 Aug 2006
doi: 10.1242/dev.02495

This Article
Right arrow Full Text (PDF)
Right arrowOA All Versions of this Article:
dev.02495v1
133/17/3305    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muro, I.
Right arrow Articles by Hay, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muro, I.
Right arrow Articles by Hay, B. A.

Research article

The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process


Israel Muro*, Deborah L. Berry, Jun R. Huh, Chun Hong Chen, Haixia Huang, Soon Ji Yoo, Ming Guo, Eric H. Baehrecke, and Bruce A. Hay
* Author for correspondence (e-mail: imuro{at}caltech.edu)

Caspase family proteases play important roles in the regulation of apoptotic cell death. Initiator caspases are activated in response to death stimuli, and they transduce and amplify these signals by cleaving and thereby activating effector caspases. In Drosophila, the initiator caspase Nc (previously Dronc) cleaves and activates two short-prodomain caspases, Dcp-1 and Ice (previously Drice), suggesting these as candidate effectors of Nc killing activity. dcp-1-null mutants are healthy and possess few defects in normally occurring cell death. To explore roles for Ice in cell death, we generated and characterized an Ice null mutant. Animals lacking Ice show a number of defects in cell death, including those that occur during embryonic development, as well as during formation of adult eyes, arista and wings. Ice mutants exhibit subtle defects in the destruction of larval tissues, and do not prevent destruction of salivary glands during metamorphosis. Cells from Ice animals are also markedly resistant to several stresses, including X-irradiation and inhibition of protein synthesis. Mutations in Ice also suppress cell death that is induced by expression of Rpr, Wrinkled (previously Hid) and Grim. These observations demonstrate that Ice plays an important non-redundant role as a cell death effector. Finally, we demonstrate that Ice participates in, but is not absolutely required for, the non-apoptotic process of spermatid differentiation.


This article has been cited by other articles:


Home page
 DevelopmentHome page
A. Melendez and T. P. Neufeld
The cell biology of autophagy in metazoans: a developing story
Development, July 15, 2008; 135(14): 2347 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
L. Zhong and J. M. Belote
The testis-specific proteasome subunit Pros{alpha}6T of D. melanogaster is required for individualization and nuclear maturation during spermatogenesis
Development, October 1, 2007; 134(19): 3517 - 3525.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Gonzalez-Estevez, D. A. Felix, A. A. Aboobaker, and E. Salo
Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation
PNAS, August 14, 2007; 104(33): 13373 - 13378.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
N. Link, P. Chen, W.-J. Lu, K. Pogue, A. Chuong, M. Mata, J. Checketts, and J. M. Abrams
A collective form of cell death requires homeodomain interacting protein kinase
J. Cell Biol., August 9, 2007; 178(4): 567 - 574.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Mathieu, H.-H. Sung, C. Pugieux, J. Soetaert, and P. Rorth
A Sensitized PiggyBac-Based Screen for Regulators of Border Cell Migration in Drosophila
Genetics, July 1, 2007; 176(3): 1579 - 1590.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Zheng, C. J. Stratton, K. Morozumi, J. Jin, R. Yanagimachi, and W. Yan
Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility
PNAS, April 17, 2007; 104(16): 6852 - 6857.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
D. A. Primrose, S. Chaudhry, A. G. D. Johnson, A. Hrdlicka, A. Schindler, D. Tran, and E. Foley
Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster
J. Cell Sci., April 1, 2007; 120(7): 1189 - 1199.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Huh, I. Foe, I. Muro, C. H. Chen, J. H. Seol, S. J. Yoo, M. Guo, J. M. Park, and B. A. Hay
The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers
J. Biol. Chem., January 19, 2007; 282(3): 2056 - 2068.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2006