spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 2 Oct 2008
doi: 10.1242/dev.025437

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.025437v1
135/21/3599    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Park, E. J.
Right arrow Articles by Moon, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Park, E. J.
Right arrow Articles by Moon, A. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research article: Development and Disease

An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart


Eon Joo Park, Yusuke Watanabe, Graham Smyth, Sachiko Miyagawa-Tomita, Erik Meyers, John Klingensmith, Todd Camenisch, Margaret Buckingham, and Anne M. Moon*
* Author for correspondence (e-mail: anne.moon{at}genetics.utah.edu)

In order to understand how secreted signals regulate complex morphogenetic events, it is crucial to identify their cellular targets. By conditional inactivation of Fgfr1 and Fgfr2 and overexpression of the FGF antagonist sprouty 2 in different cell types, we have dissected the role of FGF signaling during heart outflow tract development in mouse. Contrary to expectation, cardiac neural crest and endothelial cells are not primary paracrine targets. FGF signaling within second heart field mesoderm is required for remodeling of the outflow tract: when disrupted, outflow myocardium fails to produce extracellular matrix and TGF{beta} and BMP signals essential for endothelial cell transformation and invasion of cardiac neural crest. We conclude that an autocrine regulatory loop, initiated by the reception of FGF signals by the mesoderm, regulates correct morphogenesis at the arterial pole of the heart. These findings provide new insight into how FGF signaling regulates context-dependent cellular responses during development.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
K. Sugiura, Y.-Q. Su, Q. Li, K. Wigglesworth, M. M. Matzuk, and J. J. Eppig
Fibroblast Growth Factors and Epidermal Growth Factor Cooperate with Oocyte-Derived Members of the TGFbeta Superfamily to Regulate Spry2 mRNA Levels in Mouse Cumulus Cells
Biol Reprod, November 1, 2009; 81(5): 833 - 841.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. D. Combs and K. E. Yutzey
Heart Valve Development: Regulatory Networks in Development and Disease
Circ. Res., August 28, 2009; 105(5): 408 - 421.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J.-H. Seo, A. Suenaga, M. Hatakeyama, M. Taiji, and A. Imamoto
Structural and Functional Basis of a Role for CRKL in a Fibroblast Growth Factor 8-Induced Feed-Forward Loop
Mol. Cell. Biol., June 1, 2009; 29(11): 3076 - 3087.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Rochais, K. Mesbah, and R. G. Kelly
Signaling Pathways Controlling Second Heart Field Development
Circ. Res., April 24, 2009; 104(8): 933 - 942.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. R. Chien, I. J. Domian, and K. K. Parker
Cardiogenesis and the Complex Biology of Regenerative Cardiovascular Medicine
Science, December 5, 2008; 322(5907): 1494 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Zhang, Y. Lin, Y. Zhang, Y. Lan, C. Lin, A. M. Moon, R. J. Schwartz, J. F. Martin, and F. Wang
Frs2{alpha}-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis
Development, November 1, 2008; 135(21): 3611 - 3622.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2008