spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
Development ePress online publication date 24 Jan 2007
doi: 10.1242/dev.02788

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
dev.02788v1
134/5/825    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagaraj, R.
Right arrow Articles by Banerjee, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagaraj, R.
Right arrow Articles by Banerjee, U.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research report

Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye


Raghavendra Nagaraj and Utpal Banerjee*
* Author for correspondence (e-mail: banerjee{at}mbi.ucla.edu)

In the developing eye of Drosophila, the EGFR and Notch pathways integrate in a sequential, followed by a combinatorial, manner in the specification of cone-cell fate. Here, we demonstrate that the specification of primary pigment cells requires the reiterative use of the sequential integration between the EGFR and Notch pathways to regulate the spatiotemporal expression of Delta in pupal cone cells. The Notch signal from the cone cells then functions in the direct specification of primary pigment-cell fate. EGFR requirement in this process occurs indirectly through the regulation of Delta expression. Combined with previous work, these data show that unique combinations of only two pathways - Notch and EGFR - can specify at least five different cell types within the Drosophila eye.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
S. J. Warner and G. D. Longmore
Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension
J. Cell Biol., October 5, 2009; 187(1): 119 - 133.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. A. Shalaby, A. L. Parks, E. J. Morreale, M. C. Osswalt, K. M. Pfau, E. L. Pierce, and M. A. T. Muskavitch
A Screen for Modifiers of Notch Signaling Uncovers Amun, a Protein With a Critical Role in Sensory Organ Development
Genetics, August 1, 2009; 182(4): 1061 - 1076.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. T. Pickup, L. Ming, and H. D. Lipshitz
Hindsight modulates Delta expression during Drosophila cone cell induction
Development, March 15, 2009; 136(6): 975 - 982.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007