Subject collection: Chromatin & epigenetics
- Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes
Highlighted article: Upregulation of replication-dependent core histone genes by retinoic acid signaling contributes to spermatogonial differentiation in mice.
- The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo
Summary: Associations of BAF155 with other BAF complex subunits are enriched in extra-embryonic lineages prior to implantation, while changes in BAF155 levels modulate the expression of early developmental markers.
- From single genes to entire genomes: the search for a function of nuclear organization
Summary: This Review highlights the genome-wide techniques used to shed light on the mechanisms of genome folding and unravel the regulatory functions of nuclear organization.
- H19 controls reactivation of the imprinted gene network during muscle regeneration
Summary: Expression of H19 regulates muscle stem cell number and controls their entry into quiescence. Absence of H19 leads to better muscle regeneration with increased expression of the IGN genes.
- KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
Highlighted article: Cardiac-specific depletion of the H3K4 methyltransferase KMT2D causes dysregulation of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling.
- The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1
Summary: In C. elegans, depletion of the histone demethylase rbr-2 leads to axon guidance defects that can be attributed to NURF-mediated ectopic expression of the actin regulator wsp-1.
- RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression
Highlighted article: RING1 proteins, which are essential components of Polycomb repressive complex-1, control proximal-distal patterning of the mouse forelimb by integrating developmental signals to regulate MEIS expression.
- Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors
Summary: Bmi1 is required to prevent postnatal degeneration of cone photoreceptors and bipolar neurons, while BMI1 inactivation in human embryonic stem cells impairs cone terminal differentiation.
- A novel role for Ascl1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT
Summary: The proneural factor ASCL1 recruits HDAC1 to repress VegT-induced, but not Nodal-induced, mesendoderm formation via a previously uncharacterized N-terminal domain.
- Single-stranded DNA binding proteins are required for LIM complexes to induce transcriptionally active chromatin and specify spinal neuronal identities
Highlighted article: In the mouse spinal cord, single-stranded DNA binding proteins are key cofactors in LIM-containing complexes, recruiting histone-modifying enzymes to promote transcription.