Subject collection: Exploring the Nucleus
- Emery–Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane
Highlighted Article: Emerin is a tail-anchored protein of the inner nuclear membrane. Here, post-translational membrane insertion of emerin is analyzed, revealing a prominent role for the TRC40 pathway.
- Dynamic distributions of long double-stranded RNA in Tetrahymena during nuclear development and genome rearrangements
Summary: Long double-stranded RNAs are differentially expressed and distributed during nuclear differentiation to affect small RNA production and DNA rearrangements in Tetrahymena.
- Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis
Summary: Identification of a new fatty acid synthase inhibitor for nuclear division by a chemical genetic screen revealed a link between nuclear envelope expansion and faithful chromosome segregation in a closed mitosis.
- Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding
Summary: NTF2 reduces the diameter of the NPC, nuclear import of large cargos and nuclear size in a Ran-binding-dependent manner, in both Xenopus and mammalian cells.
- DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation
Highlighted Article: The RNA-binding proteins DAZL and CPEB1 cooperate to regulate mRNA translation and protein synthesis during the meiotic cell cycle in mouse oocytes.
- Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1
Summary: NOL1 is a TERC-binding protein and represents a new method by which telomerase activates transcription of the cyclin D1 gene, thus maintaining cell proliferation capacity.
- Sharing of mitotic pre-ribosomal particles between daughter cells
Summary: Maturation of mitotic pre-rRNAs is transiently arrested during mitosis by a CDK1–cyclin-B-dependent mechanism. Strikingly, during their maturation process, mitotic pre-rRNAs localize in reforming nucleoli.