Subject collection: Human Development
- The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation
- Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids
Summary: In human cerebral organoids, depletion of the tumor suppressor retinoblastoma protein disrupts proliferation, promotes entry into S-phase, and causes increased apoptosis and aberrant neuronal migration.
- Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo
Summary: Cord blood-borne fibroblasts, a population of adherent cells derived from human umbilical cord blood, generate a miniature bone/marrow organ when transplanted in vivo into mice.
- In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development
Summary: Human embryonic stem cell-derived intestinal organoids can be patterned into duodenum-like or ileum-like tissue, recapitulating in vivo human development.
- Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism
Summary: Expansion of human embryonic liver progenitors in organoid culture is promoted by branched-chain amino acid metabolism, while dietary restriction in pregnant mice impairs embryonic liver bud growth.
- Ethical issues in human organoid and gastruloid research
Summary: This Spotlight article summarizes some of the important ethical issues associated with research involving human organoids and other complex self-organized structures.
- Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish
Summary: This Development at a Glance article summarises how knowledge gained from developmental biology can be used to guide human in vitro organogenesis, and discusses the potential applications of this technology.
- Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis
Summary: This Review article discusses the basic physical and biological principles that underlie the self-organization of embryonic stem cells into organoids, and how this informs human development.
- Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion