Subject collection: Musculoskeletal system
- Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse
Summary: The genetic deletion of Bmpr1a in mice reveals a dual function for BMP signaling in restricting preosteoblast proliferation and promoting osteoblast activity, probably via regulation of mTORC1.
- c-Raf promotes angiogenesis during normal growth plate maturation
Summary: The chondrocyte-specific ablation of c-Raf in mice results in a delay in vascular invasion and growth plate maturation due to increased ubiquitin-dependent degradation of VEGF.
- Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
Summary: During bone formation in neonatal mice, chondrocytic expression of the receptor tyrosine kinase Ephrin B2 regulates cartilage degradation and subsequent osteoclastic destruction of the cartilage matrix.
- Inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ signaling mediates delayed myogenesis in Duchenne muscular dystrophy fetal muscle
Summary: The absence of dystrophin in human fetal muscle alters IP3 signaling pathways and consequently causes a delay in myogenesis and myofiber commitment.
- Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis
Summary: The endothelial versus myogenic fate choice in the somite requires Foxc1/2. In conditional Foxc1/2 mutants, endothelial cell loss compromises migration of myogenic cells to the limb.
- H19 controls reactivation of the imprinted gene network during muscle regeneration
Summary: Expression of H19 regulates muscle stem cell number and controls their entry into quiescence. Absence of H19 leads to better muscle regeneration with increased expression of the IGN genes.
- Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development
Summary: Increased RA levels in developing zebrafish have multiple effects on skull formation, ranging from gain to loss of bone, and depending on allelic strength, developmental stage and cellular context.
- A shared role for sonic hedgehog signalling in patterning chondrichthyan gill arch appendages and tetrapod limbs
Summary: Shh signalling polarises skate gill arches and maintains proliferative expansion of gill arch appendage endoskeletal progenitors, mirroring the function of Shh signalling in the tetrapod limb.
- Restricting calcium currents is required for correct fiber type specification in skeletal muscle
Summary: Developmental splicing of CaV1.1 restricts calcium currents in skeletal muscle, which are critical for activity-dependent regulation of fiber type specification and the prevention of mitochondrial damage.
- FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth
Summary: Conditional ablation of Fgfr1 and Fgfr2 in the osteoblast lineage in mouse reveals a feed-forward loop controlling FGFR3 signaling in growth plate chondrocytes.