Subject collection: Neural development
- Self-organising aggregates of zebrafish retinal cells for investigating mechanisms of neural lamination
Summary: Müller glia cells, but not retinal pigmented epithelial cells, are crucial for retinal cell lamination in retinal organoids grown in vitro.
- Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids
Summary: In human cerebral organoids, depletion of the tumor suppressor retinoblastoma protein disrupts proliferation, promotes entry into S-phase, and causes increased apoptosis and aberrant neuronal migration.
- Using brain organoids to understand Zika virus-induced microcephaly
Summary: This Spotlight article summarises the latest advances in using cerebral organoids to model Zika virus infection and the resulting pathology.
- Regulatory logic driving stable levels of defective proventriculus expression during terminal photoreceptor specification in flies
Summary: The activities of two cis-regulatory enhancers, which integrate combinatorial transcription factor input, feedback and redundancy, are coordinated to drive dve expression in the Drosophila eye.
- TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway
Summary: Transactivation response element RNA-binding protein (TRBP) acts as a transcriptional coactivator of the Notch pathway and regulates neural stem cells during brain development in mice.
- Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion
Summary: PI3-kinase-dependent regulation of DE-cadherin controls cell adhesion between Drosophila neuroblasts and neighboring cortex glia, and between neuroblasts and their daughter cells.
- Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster
Summary: Drosophila A2BP1 regulates sensory organ specification by potentiating Notch signaling, forming part of the Suppressor of Hairless complex and acting in a context-dependent manner.
- The assembly of developing motor neurons depends on an interplay between spontaneous activity, type II cadherins and gap junctions
- JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling
Summary: The C. elegans histone demethylase JMJD-1.2 is required non-cell-autonomously for axon guidance and modulates the transcription of Hh-related genes, revealing a role for Hh signaling in C. elegans neural development.
- A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons
Summary: A novel boundary that subdivides the mouse mesodiencephalic floor plate into two microdomains, each giving rise to distinct types of neurons, is identified.