Subject collection: Neural development
- Morphogenesis of neurons and glia within an epithelium
Summary: Sensory neurons and glia, which breach the epithelial barrier between an organism and its environment, exhibit epithelial properties themselves and develop through mechanisms shared with other epithelia.
- The HMG box transcription factors Sox1a and Sox1b specify a new class of glycinergic interneuron in the spinal cord of zebrafish embryos
Summary: A novel spinal neuronal V2 subtype, V2s, is described in zebrafish embryos and proposed to be required for fast escape responses.
- Ecrg4 deficiency extends the replicative capacity of neural stem cells in a Foxg1-dependent manner
Summary: Ecrg4-deficient mice reveal that loss of Ecrg4 not only maintains proliferation of neural stem cells in vitro and in vivo, but also enhances spatial recognition and memory.
- A crucial role for Arf6 in the response of commissural axons to Slit
Highlighted Article: At the ventral midline, developing commissural axons increase Slit sensitivity through a positive-feedback mechanism that is Arf6 mediated and driven by Robo1 receptor endocytic recycling.
- Transcriptional control of morphological properties of direction-selective T4/T5 neurons in Drosophila
Summary: RNA interference identifies SoxN and Sox102F as key regulators of the morphological properties of a neuronal type of the fruit fly visual system that computes the direction of motion.
- Co-option of the PRDM14-CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution
Highlighted Article: A comparison of the functions and expression patterns of PRDM14 orthologues within deuterostomes reveals a framework for addressing how pluripotency transcriptional networks have evolved.
- A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait
Highlighted Article: Vertebrates develop nervous systems with numerous cells. Study of cell proliferation in the lamprey nervous system links this to the evolution of a ventricular proliferation zone regulated by Notch signalling.
- Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
Summary: Live morphological staging reveals common strengths and limitations of differentiating 3D retinal organoid cultures across multiple human pluripotent stem cell lines.
- Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
Summary: This Review discusses the mechanisms that regulate neuronal migration and associated disorders, with particular focus on appropriate in vivo and in vitro model systems.
- The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration
Summary: GLI3 plays an important, non-cell-autonomous role in maintaining the organization of the precerebellar migratory streams and the final positioning of precerebellar neurons.