Subject collection: Neural development
- A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea
Summary: Planar cell polarity proteins function in cochlear supporting cells to guide peripheral axon guidance and the innervation of outer hair cells by the spiral ganglion.
- Yif1 associates with Yip1 on Golgi and regulates dendrite pruning in sensory neurons during Drosophila metamorphosis
Summary: Two novel Drosophila proteins, Yif1 and Yip1, associate with each other and regulate Golgi integrity to act as novel players of dendrite pruning in sensory neurons during early metamorphosis.
- Genetic screening and multipotency in rhesus monkey haploid neural progenitor cells
Summary: Monkey haploid neural progenitor cells are proliferative and multipotent, yielding a range of neural subtypes that can serve as powerful tools to identify neural toxicant targets via high-throughput genetic screening.
- Lineage-guided Notch-dependent gliogenesis by Drosophila multi-potent progenitors
Summary: Drosophila multi-potent progenitors produce brain region-specific glial populations, including astrocyte-like and ensheathing glia, with Notch signaling promoting the switch to glial fate and subsequent expansion.
- Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain
Highlighted Article: Notch3 signalling selectively controls neural stem cell stemness through the activity of the Hey1 transcription factor, independently of its molecular regulation of neural stem cell quiescence.
- The developmental origin of brain tumours: a cellular and molecular framework
Summary: Lineage-tracing work in glioma and medulloblastoma reveals similarities between neuronal development and brain tumours, identifying potential new therapeutic avenues that exploit vulnerabilities in tumour growth patterns.
- Four specific immunoglobulin domains in UNC-52/Perlecan function with NID-1/Nidogen during dendrite morphogenesis in Caenorhabditis elegans
Summary: Specific immunoglobulin domain-containing isoforms of the basement membrane protein UNC-52/Perlecan act in concert with the basement membrane protein NID-1/Nidogen via UNC-6/Netrin signaling to promote secondary branching of PVD somatosensory dendrites.
- Understanding axon guidance: are we nearly there yet?
Summary: This Review discusses how crosstalk between different families of axon guidance receptors and cues functions during axonal navigation, highlighting recent studies that question the textbook model of axon guidance.
- Spatial regulation of microtubule disruption during dendrite pruning in Drosophila
Summary: Kinesin-dependent uniform plus-end-in microtubule organization is required for efficient c4da neuron microtubule breakdown and dendrite pruning in the Drosophila PNS during early pupal phase.
- The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate
Summary: Chemical and genetic disruption of the Wnt-PCP pathway disrupts apical actomyosin contraction and cell rearrangements essential for tissue folding, resulting in neural tube closure defects such as spina bifida.