Subject collection: Neural development
- A key role for foxQ2 in anterior head and central brain patterning in insects
Summary: foxQ2 and six3 form a regulatory module at the top of the gene network governing anterior development of the Tribolium castaneum embryo.
- Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons
Summary: The regulation of somatostatin (SST) and parvalbumin (PV) mouse cortical interneurons is mediated by Coup-TF1- and Coup-TF2-driven Sox6 expression, identifying a transcriptional pathway that controls SST-PV fate.
- Soluble APP functions as a vascular niche signal that controls adult neural stem cell number
Summary: Endothelium-derived soluble amyloid precursor protein negatively regulates the growth of neural stem cells to control neural stem cell number in the subventricular zone of the adult mouse brain.
- Programming and reprogramming the brain: a meeting of minds in neural fate
Summary: This Meeting Review discusses recent progress in our understanding of neuronal programming, highlighting some of the common features of cell fate determination during development and directed reprogramming.
- Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina
Summary: Combgap acts as a novel negative regulator of Eya-So in transcriptional outputs that coordinate cell cycle exit with the transition to differentiation during Drosophila retinal development.
- Convergence of signaling pathways underlying habenular formation and axonal outgrowth in zebrafish
Summary: Development of dHb neurons and posteriorly directed outgrowth of their axons are regulated by Shh, Wnt, Fgf, and chemokine signaling pathways in zebrafish.
- VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels
Summary: NRP1 plays a dual role in retinal ganglion cells and in vascular endothelial cells to organise axons along the optic pathway between the mouse retina and diencephalon.
- MicroRNAs in neural development: from master regulators to fine-tuners
Summary: This Review summarizes the main functions of microRNAs in several aspects of neural development, including neurogenesis, migration, axon and dendrite development, and synaptic plasticity.
- PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration
Summary: PDGF-A and its receptor control Xenopus neural crest migration by promoting EMT and contact inhibition of locomotion, acting via N-cadherin regulation at early stages of development and working as chemoattractant later.
- The fusogen AFF-1 can rejuvenate the regenerative potential of adult dendritic trees by self-fusion
Summary: Ectopic expression of the AFF-1, a protein that regulates self-fusion, can rejuvenate the regenerative potential of dendrites following injury in aging C. elegans.