Table of Contents
Research Articles
DEVELOPMENT AND DISEASE
This issue
Other journals from The Company of Biologists
Spotlight – Jayaraj Rajagopal
The lung is a perfect lens with which to ask all the questions I've ever wanted to ask
Jayaraj Rajagopal is an Associate Professor of Medicine at Harvard Medical School and a PI at the Center for Regenerative Medicine at Massachusetts General Hospital, where his lab works on the development and regeneration of the lung. Winner of the ISSCR's Susan Lim Young Investigator Award, Jay discusses his transition from the bedside to the bench and his optimism for basic research and its translation.
Hypothesis – On the evolution of bilaterality
How bilaterality evolved and whether it evolved once or several times independently is a fundamental issue in evolutionary developmental biology. In a new Hypothesis article, Grigory Genikhovich and Ulrich Technau evaluate various theories of the evolutionary emergence of animal bilaterality, based on what can be learnt from early branching animal clades, especially from Cnidaria.
Review – Can injured adult CNS axons regenerate by recapitulating development?
Brett J. Hilton and Frank Bradke highlight the mechanisms underlying CNS developmental axon growth and adult regeneration failure in a new Review article, exploring the hypothesis that adult central neurons can regenerate by recapitulating development.
The people behind the papers – Simon Lane and Keith Jones
First author Simon Lane and his PI Keith Jones, from the University of Southampton, UK, spoke to the Node about their new Research article published this week in Development, revealing the unique ability of mouse oocytes to sense DNA damage by rapid kinetochore checkpoint activation.
Articles of interest in our sister journals
Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation
Kim-Vy Nguyen-Ngoc, Vanesa L. Silvestri, Dan Georgess, Amanda N. Fairchild, Andrew J. Ewald
J Cell Sci 2017 130: 3213-3221; doi: 10.1242/jcs.208546