Table of Contents
Research Articles
DEVELOPMENT AND DISEASE
This issue
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The people behind the papers – Elena Popa and Abigail Tucker
“After what felt like hundreds of failed attempts, finally being able to see Sox2 staining under the microscope felt like a huge relief!”
First author Elena Popa and Abigail Tucker, Professor of Development and Evolution at King's College London, talk about their research into tooth development in the mouse and other organisms.
Matt Porteus (right) and Robin Lovell-Badge (left) clarify some statements made by He Jiankui. Courtesy of Vivian Tam (School of Biomedical Sciences, University of Hong Kong)
Robin Lovell-Badge gives his perspective on the recent report from Jiankui He of the world's first genome edited babies and discusses if and how clinical applications of germline genome editing in humans may be justifiable.
Developmental biology for agriculture
In the latest Spotlight for our Advocacy series, Scott Boden and Lars Østergaard argue that technological advances in sequencing, genome editing and advanced data processing should allow developmental biologists to improve crop performance as crop yields come under pressure to meet the growing human population's needs.
Demonstrating some of these principles in a new Research Article, Laura Dixon and team analyse the flowering and growth responses of a range of wheat cultivars to warmer growth temperatures.
A new Instagram account for Development
Our new Instagram account promotes the beauty of developmental biology through the work of our authors. Do join us there!
Workshop - New frontiers in the brain: unexpected roles of the choroid plexus-cerebrospinal fluid system in health and disease
Development is pleased to welcome submissions for an upcoming Special Issue on ‘Chromatin and Epigenetics’, edited by Benoit Bruneau, Haruhiko Koseki, Susan Strome and Maria-Elena Torres-Padilla. This special issue aims to showcase the best research covering the chromatin-based and epigenetic mechanisms which regulate development across the plant and animal kingdoms. Submission deadline: 31 March 2019.
PreLights – A direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila
Extensive and dynamic genome binding by a steroid hormone receptor highlights the interconnection between systemic and local cues for organ development, shows a preprint written by Christopher Uyehara and Daniel McKay and highlighted by Natalie Dye.
Catch up with other recent preLights selected for the developmental biology community.
Articles of interest in our sister journals
Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models
Kurt Reynolds, Priyanka Kumari, Lessly Sepulveda Rincon, Ran Gu, Yu Ji, Santosh Kumar, Chengji J. Zhou
Disease Models & Mechanisms 2019 12: dmm037051
Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility
Tiziana Giordano, Sudarshan Gadadhar, Satish Bodakuntla, et al.
J Cell Sci 2019 132: jcs226951