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Towards an integrated view of Wnt signaling in development
Renée van Amerongen, Roel Nusse


Wnt signaling is crucial for embryonic development in all animal species studied to date. The interaction between Wnt proteins and cell surface receptors can result in a variety of intracellular responses. A key remaining question is how these specific responses take shape in the context of a complex, multicellular organism. Recent studies suggest that we have to revise some of our most basic ideas about Wnt signal transduction. Rather than thinking about Wnt signaling in terms of distinct, linear, cellular signaling pathways, we propose a novel view that considers the integration of multiple, often simultaneous, inputs at the level of both Wnt-receptor binding and the downstream, intracellular response.


  • We thank T. Blauwkamp and J. Green for helpful discussions and reading of the manuscript. R.v.A. is supported by a long-term fellowship from the European Molecular Biology Organization (EMBO) and by a KWF fellowship from the Dutch Cancer Society. R.N. is an investigator of the Howard Hughes Medical Institute (HHMI).

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