Morpholinos for splice modificatio

Morpholinos for splice modification


Drosophila neuroblasts: a model for stem cell biology
Catarina C. F. Homem, Juergen A. Knoblich


Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key model system for neural stem cell biology and have provided key insights into the mechanisms underlying asymmetric cell division and tumor formation. More recently, they have also been used to understand how neural progenitors can generate different neuronal subtypes over time, how their cell cycle entry and exit are coordinated with development, and how proliferation in the brain is spared from the growth restrictions that occur in other organs upon starvation. In this Primer, we describe the biology of Drosophila neuroblasts and highlight the most recent advances made using neuroblasts as a model system.


  • Funding

    Work in J.A.K.'s lab is supported by the Austrian Academy of Sciences; the EU seventh framework program network EuroSyStem; the Austrian Science Fund (FWF); and an advanced grant of the European Research Council (ERC).

  • Competing interests statement

    The authors declare no competing financial interests.

View Full Text