Table of Contents
IN THIS ISSUE
DEVELOPMENT AT A GLANCE
- Glia in mammalian development and disease
Summary: This poster article reviews the origins of glia, their diverse roles during neural development and their contribution to plasticity and disease in the adult mammalian nervous system.
- Next generation limb development and evolution: old questions, new perspectives
Summary: This Review discusses novel insights into the gene regulatory networks that govern limb development, fin-to-limb transition and digit reductions during tetrapod limb evolution.
- ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm
Highlighted article: In the chick prechordal mesoderm, the Nodal precursor proNodal acts via a non-canonical route to inhibit BMP signalling and thus maintain Shh expression
- De novo DNA methylation through the 5′-segment of the H19 ICR maintains its imprint during early embryogenesis
Highlighted article: In the mouse early embryo, H19 ICR imprinting is achieved through maternally inherited DNMT3A- and DNMT3L-mediated de novo methylation and requires a specific 5′ region of the locus.
- A local difference in Hedgehog signal transduction increases mechanical cell bond tension and biases cell intercalations along the Drosophila anteroposterior compartment boundary
Highlighted article: Linking intercellular signaling and mechanical regulators of cell behavior, differential Hh activity in the Drosophila wing disc regulates the shape of the anterior-posterior boundary.
- Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation
Highlighted article: Loss of Hox6 function in the mouse pancreatic mesenchyme results in a drastic reduction of endocrine cells as a result of decreased mesenchymal Wnt signaling.
- The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos
Summary: The conserved Tor and autophagy metabolic sensing pathways are required for a burst of spatially regulated yolk catabolism during Drosophila cellularization.
- Excitability governs neural development in a hippocampal region-specific manner
Summary: In the developing mouse hippocampus, intrinsic neuronal excitability does not alter CA3 neuron development but regulates spine formation and synaptic transmission in CA1 neurons.
- Genome-wide assessment of differential effector gene use in embryogenesis
Highlighted article: Spatially distinct populations of the early sea urchin embryo display profound differences in effector gene expression before morphological differences can be distinguished.
- Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle
Summary: A three dimensional in silico model of C. elegans predicts that adult germ cells are subject to a mechanical feedback on the cell cycle akin to contact inhibition.
- Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus
Summary: The endochondral ossification of the malleus, an ossicle of the mouse inner ear, occurs around capillaries and is mediated by the AP-1 transcription factor Fosl1.
- Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice
Summary: In the mouse cerebellum, Aspm depletion causes increased DNA damage and impaired mitosis, leading to granule cell progenitor apoptosis. In medulloblastoma, Aspm sustains tumor growth.
- Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina
Summary: In the fish eye, Hh signalling from the ventral forebrain regulates spatial identity in the retina by promoting foxd1 expression. This role is required only in the presence of Fgf activity.
- Maternal BCAS2 protects genomic integrity in mouse early embryonic development
Summary: In the early mouse embryo, DNA damage repair is achieved through BCAS2-mediated control of the RPA complex, a key regulator of genome integrity.
- Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning
Summary: Foxi3 shapes tooth morphogenesis in mice by suppressing the formation of signaling centers in the tooth crown and inhibiting the acquisition of root and ameloblast cell fates.
TECHNIQUES AND RESOURCES
- Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment
Highlighted article: A previously undescribed intermediary membrane-lined multivesicular compartment is required for subcellular lumen formation in maturing Drosophila tracheal cells.
- ChtVis-Tomato, a genetic reporter for in vivo visualization of chitin deposition in Drosophila
Summary: The deposition of chitin, a key component of the insect exoskeleton, can now be followed in living Drosophila pupae with ChtVis-Tomato, an in vivo chitin reporter.
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science