Table of Contents
IN THIS ISSUE
- Direct neuronal reprogramming: learning from and for development
Summary: This Review discusses how developmental studies have set the stage for direct neuronal reprogramming approaches and how direct conversion can shed light on unsolved questions in developmental biology.
STEM CELLS AND REGENERATION
- Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff
Summary: The maintenance of Drosophila type II neuroblast identity and self-renewal requires Notch-mediated inhibition of negative feedback of Earmuff on its activator Pointed P1.
- Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing
Summary: Postnatal mouse skin exhibits a decline in its ability to regenerate hair follicles in the wound bed and this can be partially reversed by inhibiting dermal β-catenin activation.
- Cell adhesion in plants is under the control of putative O-fucosyltransferases
Highlighted article: Pectin-related signaling, rather than absolute pectin levels, are proposed to contribute to cell adhesion during growth and development in Arabidopsis thaliana.
- Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis
Summary: Detailed morphogenetic analyses reveal the relative contributions of Wnt pathway genes to the regulation of convergence and extension cell behaviors during zebrafish palate development.
- A unique stylopod patterning mechanism by Shox2-controlled osteogenesis
Highlighted article: A Shox2-coordinated transcriptional program functions in the osteogenic lineage to regulate Hox-TALE factors and skeletogenesis, and to pattern the mouse limb.
- Gestational stress induces the unfolded protein response, resulting in heart defects
Highlighted article: Short-term gestational hypoxia in developing mouse embryos induces common types of heart defects by activating the unfolded protein response.
- Pins is not required for spindle orientation in the Drosophila wing disc
Highlighted article: Mud (Drosophila NuMA), a crucial spindle orientation factor, does not require its binding partner Pins (Drosophila LGN) to localize or function in the Drosophila imaginal wing disc.
- A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex
Summary: The transcription factors Hoxa2, Meis and Pbx act cooperatively on an evolutionarily conserved region downstream of Hmx1 to regulate Hmx1 expression and craniofacial development.
- Alk1 controls arterial endothelial cell migration in lumenized vessels
Summary: Cell tracking in a zebrafish model of hereditary hemorrhagic telangiectasia reveals that the primary defect leading to arteriovenous malformations is misdirected EC migration within lumenized arteries.
- Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer
Summary: During formation of the Kupffer's vesicle (KV) – the left-right organizer in zebrafish – Eph/ephrin signaling prevents KV cells from intermingling with adjacent cells.
- The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2
Summary: Conditional deletions of Nkx2.2 in the mouse intestine reveal that Lmx1a functions downstream of Nkx2.2 in serotonin-expressing enterochromaffin cells and regulates Tph1 – a key serotonin synthesis enzyme.
- Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin
Summary: The analysis of Drosophila embryos lacking APC reveals a diverse set of post-translational modifications that are dependent on APC, one of which regulates β-catenin abundance.
- A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex
Summary: Cell fate specification and migration in the zebrafish pineal complex are regulated by a network of at least three transcription factors: Tbx2b, Flh and Nr2e3.
- Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus
Summary: During zebrafish tuberal/anterior hypothalamus development, Shh and Rx3 govern the formation of a distinct progenitor domain that elaborates pattern through its anisotropic growth and differentiation.
- Drosophila dany is essential for transcriptional control and nuclear architecture in spermatocytes
Summary: The nuclear protein Dany associates with euchromatic regions in Drosophila spermatocytes, controls the spermatocyte gene expression program, and regulates chromatin-nuclear envelope interactions.
TECHNIQUES AND RESOURCES
- The FaceBase Consortium: a comprehensive resource for craniofacial researchers
Summary: The FaceBase Consortium is a dynamic, comprehensive resource of craniofacial development, with hundreds of datasets that are freely available to the research community at the FaceBase Hub website.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science