The plant hormone auxin triggers complex growth and developmental processes. Its underlying molecular mechanism of action facilitates rapid switching between transcriptional repression and gene activation through the auxin-dependent degradation of transcriptional repressors. The nuclear auxin signaling pathway consists of a small number of core components. However, in most plants each component is represented by a large gene family. The modular construction of the pathway can thus produce diverse transcriptional outputs depending on the cellular and environmental context. Here, and in the accompanying poster, we outline the current model for TIR1/AFB-dependent auxin signaling with an emphasis on recent studies.
The authors declare no competing or financial interests.
Research in the authors' laboratory is supported by a grant from the National Institutes of Health [GM43644 to M.E.] and grants from the Gordon and Betty Moore Foundation (to M.E.) and the Howard Hughes Medical Institute (to M.E.). Deposited in PMC for release after 12 months.
Development at a Glance
A high-resolution version of the poster is available for downloading in the online version of this article at http://dev.biologists.org/content/143/18/3226/F1.poster.jpg