Table of Contents
IN THIS ISSUE
- Regulation and plasticity of intestinal stem cells during homeostasis and regeneration
Summary: This Review discusses how stem and progenitor cells contribute to intestinal homeostasis and regeneration, and how they are regulated by different signaling pathways and systemic signals.
- From the stem of the placental tree: trophoblast stem cells and their progeny
Summary: This Review discusses the derivation and differentiation of TSCs, highlighting the signalling cascades and transcription factor circuits that govern TSC self-renewal and differentiation.
STEM CELLS AND REGENERATION
- Regulation of self-renewing neural progenitors by FGF/ERK signaling controls formation of the inferior colliculus
Summary: FGF/ERK signaling controls the formation of the mouse inferior colliculus by maintaining a neural progenitor zone and by regulating cell survival, polarity and specification.
- Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells
Summary: Forced expression of the catalytic domain of JMJD3 together with lineage-defining transcription factors can dramatically accelerate the differentiation of human PSCs.
- Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate
- Mapping lineage progression of somatic progenitor cells in the mouse fetal testis
Highlighted Article: Somatic progenitor cell populations in the mouse testis are defined by progressive lineage-specific acquirement of WT1, HES1, SOX9 and GLI1 beginning at the time of sex determination.
- A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis
- Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers
- Ezh2 restricts the smooth muscle lineage during mouse lung mesothelial development
Summary: The PRC component Ezh2 acts cell-autonomously in the developing mouse lung mesothelium to repress smooth muscle differentiation and allow appropriate cell fate decisions to occur.
- Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints
Summary: Analyses of Drosophila BMP ligands suggest that structural changes based on N-glycosylation motifs are subject to evolutionary constraints and can impact developmental processes.
- Impaired removal of H3K4 methylation affects cell fate determination and gene transcription
Summary: The catalytic activity of the histone demethylase RBR-2 is required for cell fate determination in C. elegans and for regulating the epigenetic signature of enhancers and promoters.
- The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons
Summary: During hypothalamus development in mice, Isl1 is expressed in several subpopulations of developing arcuate neurons and plays crucial roles in specifying their cell fate.
- sequoia controls the type I>0 daughter proliferation switch in the developing Drosophila nervous system
Summary: During Drosophila embryonic CNS development, the zinc-finger protein Sequoia interacts with the Notch pathway to control lineage progression.
- Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors
Summary: Genome-editing approaches in zebrafish reveal that distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations.
- Vegfa signals through ERK to promote angiogenesis, but not artery differentiation
Summary: ERK acts as a specific effector of Vegfa signaling to induce angiogenic genes during vascular sprouting in zebrafish.
- IKKε inhibits PKC to promote Fascin-dependent actin bundling
Summary: The protein kinase IKKϵ is active at the growing tip of Drosophila bristles and prevents excess PKC activation during bristle actin bundle organization and morphogenesis.
- Alteration of Nrp1 signaling at different stages of olfactory neuron maturation promotes glomerular shifts along distinct axes in the olfactory bulb
Summary: During olfactory bulb development in mice, different axonal targeting outcomes are dependent on the timing of Nrp1/Sema3A signaling.
- β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis
Summary: The conditional modulation of β-catenin activity in late hypertrophic chondrocytes locally regulates osteoclast differentiation and the transdifferentiation of chondrocytes into osteoblasts.
- TGFβ and FGF promote tendon progenitor fate and act downstream of muscle contraction to regulate tendon differentiation during chick limb development
Summary: During chick limb development, FGF and TGFβ act independently of each other and downstream of mechanical forces to control tendon formation.
- Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages
Summary: Ciona Tbx1, Ebf and Mrf homologs form an ancient conserved regulatory state for pharyngeal muscle specification, whereas their regulatory relationships are more evolutionarily variable.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science