Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Workshops and Meetings
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Development
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Development

  • Log in
Advanced search

RSS  Twitter  Facebook  YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Workshops and Meetings
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
IN THIS ISSUE
FGF signalling: making matrix in the lung
Development 2017 144: e2403
  • Article
  • Info & metrics
Loading

Embedded Image

Alveologenesis – the repeated division and growth of alveoli to expand the surface area in the lung – is one of the least understood stages of postnatal lung development. Defective alveologenesis results in bronchopulmonary dysplasia, a disorder often observed in premature infants. FGF signalling and the extracellular matrix (ECM) protein elastin are known to be important for alveologenesis, but the underlying mechanisms are poorly understood. On p. 4563, Xin Sun and colleagues dissect the roles of FGFR3 and FGFR4 in alveologenesis. Using both global and conditional Fgfr3;4 double-mutant mouse models, they show that the earliest apparent phenotype – preceding any defects in alveolar organisation – is the improper deposition of elastin fibres. Levels of elastin protein are initially unchanged, but fibre organisation is disrupted, suggesting that this may be the underlying cause of the alveolar simplification observed in the mutants. Furthermore, the phenotype can be partially rescued by depletion of Mfap5, a regulator of elastin deposition that is upregulated in the Fgfr3;4 mutant. Lineage-specific inactivation of Fgfr3;4 demonstrated that normal alveologenesis requires functional Fgfr3 and Fgfr4 in the mesenchyme but not the epithelium, which is consistent with the known role of fibroblasts in ECM organisation. The authors suggest that a defective elastin ECM physically interferes with alveolar septa formation, resulting in simplified alveoli characteristic of bronchopulmonary dysplasia.

  • © 2017. Published by The Company of Biologists Ltd
Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

Email

Thank you for your interest in spreading the word on Development.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
FGF signalling: making matrix in the lung
(Your Name) has sent you a message from Development
(Your Name) thought you would like to see the Development web site.
Share
FGF signalling: making matrix in the lung
Development 2017 144: e2403
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
FGF signalling: making matrix in the lung
Development 2017 144: e2403

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
  • Info & metrics

Related articles

Cited by...

More in this TOC section

  • Tbx6 seals mesodermal fate in the tail bud
  • Braving the cold with β-Tubulin 97EF
Show more IN THIS ISSUE

Similar articles

Other journals from The Company of Biologists

Journal of Cell Science

Journal of Experimental Biology

Disease Models & Mechanisms

Biology Open

Advertisement

A new Editor-in-Chief for Development

http://dev.biologists.org/sites/default/files/Snippet/0318_News.jpg

“I'm very keen that Development continues to innovate and support our community.”

We're delighted to announce the appointment of James Briscoe, Group Leader at The Francis Crick Institute, London, as our new Editor-in-Chief. Read our interview with James to find out his career and research interests, the importance of interdisciplinary thinking in developmental biology, and his views on the current state and future opportunities in scientific publishing. Also, check out the Editorial from Sarah Bray, Kate Storey and Katherine Brown to learn more about the announcement, and about our recent community consultation.


Review – Developing in 3D: the role of CTCF in cell differentiation

In this Review, Rodrigo G. Arzate-Mejía, Félix Recillas-Targa and Victor G. Corces discuss evidence linking CTCF to the control of developmental processes in various cell and tissue types through 3D organization of the genome.


From stem cells to human development ­– meeting reporter competition

In September, Development is hosting our next meeting focusing on human developmental biology. We are excited to announce a competition for a reporter to cover the meeting for the Node. The winner will get free registration to the meeting, and it’s a fantastic opportunity to practice your science communication skills - find out more here.


Spotlight ­– Susan Strome

“I realised that I could think it through on my own – I didn't require that my advisor tell me what to do or how to do it”

Recently appointed an editor at Development, we caught up with Susan to discuss her early career switch from prokaryotes to worms, her experiences of small and big science, and why teaching is so important to her.


On the Node – The people behind the papers

Development and homeostasis depend crucially on the maintenance of cell identity, and in gamete-producing tissues the somatic/germline distinction is paramount. A recent paper in Development explores how cell identity is secured in the Drosophila ovary by studying the function of the conserved tumour suppressor L(3)mbt. To find out more about the story, the Node caught up with first author Rémi-Xavier Coux and his supervisor Ruth Lehmann of the Skirball Institute at New York University School of Medicine.  


Santa Cruz Developmental Biology Meeting

Development is a proud sponsor of the upcoming Santa Cruz Developmental Biology Meeting, which takes place 11-15 August 2018 at the University of California, Santa Cruz . Registration for this meeting is now open!


Articles of interest in our sister journals

Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor
Rhian F. Walther, Mubarik Burki, Noelia Pinal, Clare Rogerson, Franck Pichaud. J Cell Sci 2018 131: jcs207779.

H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells
Erika Testa, Daniela Nardozi, Cristina Antinozzi, Monica Faieta, Stefano Di Cecca, Cinzia Caggiano, Tomoyuki Fukuda, Elena Bonanno, Lou Zhenkun, Andros Maldonado, Ignasi Roig, Monica Di Giacomo, Marco Barchi. J Cell Sci 2018 131: jcs214411.

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Alerts

About us

  • About Development
  • About the Node
  • Editors and board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Workshops and Meetings
  • The Company of Biologists

For authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Figure preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Alerts

Contact

  • Contact Development
  • Subscriptions
  • Advertising
  • Feedback

 Twitter   YouTube   LinkedIn

© 2018   The Company of Biologists Ltd   Registered Charity 277992