Table of Contents
IN THIS ISSUE
- Auxin 2016: a burst of auxin in the warm south of China
Summary: This Meeting Review discusses the research that was presented at the ‘Auxin 2016’ meeting, highlighting the latest advances in understanding auxin transport, metabolism and signaling.
- Metabolic remodeling during the loss and acquisition of pluripotency
Summary: This Review discusses the metabolic remodelling that occurs during the transitions between different states of pluripotency and commitment, both in vitro and in the early mammalian embryo.
- Neural tube closure: cellular, molecular and biomechanical mechanisms
Summary: This Review discusses the cellular, molecular and biomechanical mechanisms involved in neural tube closure, focusing on the most recent advances in the field.
STEM CELLS AND REGENERATION
- Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation
- A p53-based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration
Highlighted article: Clonal expansion of p53+ cardiomyocytes is observed in neonatal heart, pre-adolescent and adult hearts, as well as in regenerating neonatal hearts subject to three different injury models.
- R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways
Summary: R-spondin 1, a Wnt co-factor, regulates the expression of components of the parallel pathways Wnt16/DeltaC/DeltaD and Vegfa/Tgfβ1, required for specification of hematopoietic stem cells.
- Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl
Summary: A unique transcriptional program that regulates the coordination of positional information and tissue differentiation in regenerating salamander limbs and tails .
- Nipped-A regulates intestinal stem cell proliferation in Drosophila
Summary: Balanced expression of Nipped-A prevents hyperproliferation of intestinal stem cells in aged Drosophila midguts, identifying Nipped-A as a novel regulator of stem cell proliferation.
- ID4 levels dictate the stem cell state in mouse spermatogonia
Summary: The level of ID4 expression distinguishes stem cells and immediate progenitors in mammalian spermatogonial cells, while downregulation of ID4 is required for transition between the functional states.
- Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells
Summary: Optimised strategies and protocols enable a range of complex genetic manipulations directly in mouse and human neural stem cell lines.
- Snail2 and Zeb2 repress P-cadherin to define embryonic territories in the chick embryo
Summary: Sequential P-cadherin repression in the primitive streak and the neural plate defines embryonic territories during early chick embryonic development.
- Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila
Summary: Drosophila faint sausage (fas) encodes a subunit of the spliceosome activating Prp19 complex, which is essential for efficient pre-mRNA splicing.
- PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin-dependent adhesion
- Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation
Summary: Evenly distributed Trunk protein and terminally localized Torso-like combine to promote spatially restricted dimerization and activation of the receptor tyrosine kinase Torso.
- Sequential organogenesis sets two parallel sensory lines in medaka
Summary: Two parallel sensory lines in medaka share a common origin and are composed of identical organs that are, nevertheless, generated through different morphogenetic programmes.
- Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development
Summary: Selective repression of a neuronal isoform of ankyrin in epidermis depends on alternative polyadenylation at an intronic transcriptional termination site and is necessary for epidermal tissue integrity.
- Cell division and cadherin-mediated adhesion regulate lens epithelial cell movement in zebrafish
Summary: Time-lapse imaging of zebrafish lens epithelium reveals that cell division and cadherin-mediated adhesion regulate lens epithelial cell movement via modulation of epithelial tension.
TECHNIQUES AND RESOURCES
- Genome-wide identification of regulatory elements in Sertoli cells
Summary: Chromatin profiling identifies numerous putative transcriptional enhancers of genes important for sex determination and Sertoli development, and validate a novel enhancer upstream of Wt1.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science