Table of Contents
IN THIS ISSUE
- Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells
Summary: This Review article summarizes the current state-of-the-art retinal stem cell therapies, and highlights the essential role of developmental biology in moving this field forward.
- Prostate organogenesis: tissue induction, hormonal regulation and cell type specification
Summary: This Review article provides a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.
STEM CELLS AND REGENERATION
- FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition
Summary: FGF signaling is required for post-gastrula paraxial mesoderm induction through a unique mechanism that differs from its role during gastrula stage mesoderm induction.
- Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart
Summary: Three-dimensional confocal imaging reveals changes in cell morphology, behaviour and gene expression during cardiac regeneration following cryoinjury.
- The role of variant histone H2AV in Drosophila melanogaster larval hematopoiesis
Summary: A combination of homozygous mutant and RNAi analyses reveal that the variant histone H2AV is required for the normal differentiation of blood cells in Drosophila larval lymph glands.
- The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo
Summary: Satb1 regulates the cell fate choice between pluripotency and differentiation in the early mouse embryo and is a downstream target of the Fgf signalling pathway.
- Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration
Summary: Neuroepithelial cells are the predominant stem cell type to support cerebellar regeneration after injury in Zebrafish, as opposed to radial glia-like cells, which play a relatively minor role.
- MpWIP regulates air pore complex development in the liverwort Marchantia polymorpha
- Stomach curvature is generated by left-right asymmetric gut morphogenesis
- IP3R-mediated Ca2+ release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress
Summary: Intracellular Ca2+ signaling regulates protein translation and can compensate for insulin signaling in specialized neuro-hormonal cells, thus enabling Drosophila larval to pupal development under acute starvation.
- Developmental patterning of the sub-epidermal integument cell layer in Arabidopsis seeds
Summary: The sub-epidermal integument cell layer of the Arabidopsis seed coat is insensitive to endosperm growth alone and displays a unique response to fertilization.
- Estrogen modulates mesenchyme-epidermis interactions in the adult nipple
Highlighted Article: Skin-graft experiments, transcriptional profiling and growth factor treatment demonstrate that estrogen-regulated TGFβ signalling is crucial for the maintenance of the highly specialized nipple epidermis.
- Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity
Summary: Loss of expression of zinc-finger transcription factor Nerfin-1 in early-stage medullar neurons activates Notch signaling and promotes neuron-to-neuroblast reversion.
- Folate receptor 1 is necessary for neural plate cell apical constriction during Xenopus neural tube formation
Summary: A folate receptor-dependent action promotes neural tube formation by facilitating the changes in neural plate cell shape that are required during neurulation.
- A systems-level approach reveals new gene regulatory modules in the developing ear
Summary: Transcriptome analysis and knock down of select transcription factors reveals a genetic hierarchy as cells become committed to inner ear fate.
- IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture
Summary: IFT56 is key for the integrity and function of intraflagellar transport in cilia, and, consequently, for vertebrate development.
- Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis
Summary: Genetic analyses of Esama function in mutant zebrafish embryos reveal specific and redundant functions of Esama and VE-cadherin proteins in endothelial cell recognition and blood vessel morphogenesis.
- Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Summary: The transcription factor Helios regulates G1-S transition to promote neuronal differentiation of a striatopallidal neuronal subpopulation involved in motor skill acquisition.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science