Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.
The authors declare no competing or financial interests.
This work was supported by an Australian National Health and Medical Research Council Early Career Fellowship (R.T.) and by the National Institutes of Health (R01DK076602 to M.M.S.). Deposited in PMC for release after 12 months.