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Table of Contents

SPECIAL ISSUE: Human Development
August, 2018; 145 (16)

EDITORIAL

  • You have accessSubscription required
    Human development: recent progress and future prospects
    Olivier Pourquié, Katherine Brown
    Development 2018 145: dev170738 doi: 10.1242/dev.170738 Published 28 August 2018

    Summary: Our second Special Issue on human development highlights recent progress in this field, new technologies that have contributed to this progress and some of the ethical issues to consider.

SPOTLIGHTS

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    Gene editing in human development: ethical concerns and practical applications
    Janet Rossant
    Development 2018 145: dev150888 doi: 10.1242/dev.150888 Published 25 July 2018

    Summary: This Spotlight summarizes some of the ethical considerations associated with the use of gene-editing techniques in human embryos and embryo-like entities, highlighting the need for open and informed debate.

  • You have accessSubscription required
    On the origin of the human germline
    Toshihiro Kobayashi, M. Azim Surani
    Development 2018 145: dev150433 doi: 10.1242/dev.150433 Published 23 July 2018

    Summary: This Spotlight discusses the use of new in vitro models to study the origin of human primordial germ cells, prompting further consideration of the somatic cell fate decisions that occur during early human development.

  • You have accessSubscription required
    Developmentally inspired human ‘organs on chips’
    Donald E. Ingber
    Development 2018 145: dev156125 doi: 10.1242/dev.156125 Published 18 May 2018

    Summary: This Spotlight discusses the central role that developmental biology played in the early stages of organ-chip technology development and how such technology has provided insights into human physiology and disease mechanisms.

REVIEW

  • Open Access
    Human lung development: recent progress and new challenges
    Marko Z. Nikolić, Dawei Sun, Emma L. Rawlins
    Development 2018 145: dev163485 doi: 10.1242/dev.163485 Published 15 August 2018

    Summary: This Review describes how recent technological advances have shed light on the mechanisms underlying human lung development and disease, and outlines the future challenges in this field.

HUMAN DEVELOPMENT

  • Open Access
    Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney
    Rajasree Menon, Edgar A. Otto, Austin Kokoruda, Jian Zhou, Zidong Zhang, Euisik Yoon, Yu-Chih Chen, Olga Troyanskaya, Jason R. Spence, Matthias Kretzler, Cristina Cebrián
    Development 2018 145: dev164038 doi: 10.1242/dev.164038 Published 30 August 2018

    Summary: New markers for specific cell types in the developing human kidney are identified and computational approaches infer developmental trajectories and interrogate the complex network of signaling pathways and cellular transitions.

  • Open Access
    Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells
    Taiki Nakajima, Mitsuaki Shibata, Megumi Nishio, Sanae Nagata, Cantas Alev, Hidetoshi Sakurai, Junya Toguchida, Makoto Ikeya
    Development 2018 145: dev165431 doi: 10.1242/dev.165431 Published 23 August 2018

    Summary: Protocols for the differentiation of human iPSCs to somite derivatives (myotome, sclerotome, syndetome and dermatome) are developed and applied to the modeling of the bone disease fibrodysplasia ossificans progressiva.

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    Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling
    Cyrille Ramond, Belin Selcen Beydag-Tasöz, Ajuna Azad, Martijn van de Bunt, Maja Borup Kjær Petersen, Nicola L. Beer, Nicolas Glaser, Claire Berthault, Anna L. Gloyn, Mattias Hansson, Mark I. McCarthy, Christian Honoré, Anne Grapin-Botton, Raphael Scharfmann
    Development 2018 145: dev165480 doi: 10.1242/dev.165480 Published 15 August 2018

    Summary: This study develops sorting strategies to isolate specific pancreatic populations and use single-cell profiling to evaluate whether pancreatic cells derived from hPSCs mirror the process occurring in human fetuses.

  • You have accessSubscription required
    Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development
    María J. García-León, Patricia Fuentes, José Luis de la Pompa, María L. Toribio
    Development 2018 145: dev165597 doi: 10.1242/dev.165597 Published 13 August 2018

    Summary: Here, through immunohistochemistry and quantitative confocal microscopy of fetal, postnatal and adult thymus, we show that spatiotemporal regulation of Notch ligand expression in the human thymus controls niche-specific NOTCH1 signals required for dynamic T-cell development.

  • Open Access
    Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells
    Takenori Ogura, Hideya Sakaguchi, Susumu Miyamoto, Jun Takahashi
    Development 2018 145: dev162214 doi: 10.1242/dev.162214 Published 30 July 2018

    Summary: The three-dimensional induction of dorsal, intermediate and ventral spinal cord-like tissues from human pluripotent stem cells described provides a useful experimental tool for studying human spinal cord development.

  • Open Access
    Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitor-like cells in vitro
    Laure Verrier, Lindsay Davidson, Marek Gierliński, Alwyn Dady, Kate G. Storey
    Development 2018 145: dev166215 doi: 10.1242/dev.166215 Published 12 July 2018

    Summary: The first transcriptome profiling of human neuromesodermal progenitor-like cells, generation of human spinal cord progenitors from these cells and a GFP-reporter for Nkx1.2 in human embryonic stem cells.

  • Open Access
    Integrin α2 marks a niche of trophoblast progenitor cells in first trimester human placenta
    Cheryl Q. E. Lee, Margherita Y. Turco, Lucy Gardner, Benjamin D. Simons, Myriam Hemberger, Ashley Moffett
    Development 2018 145: dev162305 doi: 10.1242/dev.162305 Published 16 April 2018

    Summary: ITGA2 marks a proliferative trophoblast progenitor compartment in first trimester human placenta that appears to be regulated by NOTCH signalling and exhibits a unique combination of epithelial and mesenchymal expression characteristics.

  • Open Access
    Distinct prophase arrest mechanisms in human male meiosis
    Sabrina Z. Jan, Aldo Jongejan, Cindy M. Korver, Saskia K. M. van Daalen, Ans M. M. van Pelt, Sjoerd Repping, Geert Hamer
    Development 2018 145: dev160614 doi: 10.1242/dev.160614 Published 16 April 2018

    Summary: Histological examination and transcriptomic analysis of human meiosis-arrested spermatocytes reveals two prophase arrest mechanisms, each associated with distinct gene expression profiles implicating the involvement of different biological processes.

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    Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila

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    Maturation of heart valve cell populations during postnatal remodeling

    Alexia Hulin, Luis Hortells, M. Victoria Gomez-Stallons, Anna O'Donnell, Kashish Chetal, Mike Adam, Patrizio Lancellotti, Cecile Oury, S. Steven Potter, Nathan Salomonis, Katherine E. Yutzey
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    Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity

    Charles Nelson, Victor Ambros
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    Lmx1a drives Cux2 expression in the cortical hem through activation of a conserved intronic enhancer

    Santiago Fregoso, Brett E. Dwyer, Santos J. Franco
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    Rho-of-plant-activated root hair formation requires Arabidopsis YIP4a/b gene function

    Delphine Gendre, Anirban Baral, Xie Dang, Nicolas Esnay, Yohann Boutté, Thomas Stanislas, Thomas Vain, Stéphane Claverol, Anna Gustavsson, Deshu Lin, Markus Grebe, Rishikesh P. Bhalerao
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