Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Workshops and Meetings
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Development
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Development

  • Log in
Advanced search

RSS  Twitter  Facebook  YouTube 

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Special issues
    • Subject collections
    • Sign up for alerts
  • About us
    • About Development
    • About the Node
    • Editors and Board
    • Editor biographies
    • Travelling Fellowships
    • Grants and funding
    • Workshops and Meetings
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
    • Biology Open transfer
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contacts
    • Contacts
    • Subscriptions
    • Feedback
RESEARCH ARTICLE
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling
Thomas Volckaert, Tingting Yuan, Jie Yuan, Eistine Boateng, Seantel Hopkins, Jin-San Zhang, Victor J. Thannickal, Reinhard Fässler, Stijn P. De Langhe
Development 2019 146: dev166454 doi: 10.1242/dev.166454 Published 16 January 2019
Thomas Volckaert
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tingting Yuan
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jie Yuan
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eistine Boateng
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seantel Hopkins
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jin-San Zhang
School of Pharmaceutical Sciences and the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, ChinaDivision of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victor J. Thannickal
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Reinhard Fässler
Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stijn P. De Langhe
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Stijn P. De Langhe
  • For correspondence: sdelanghe@uabmc.edu
  • Article
  • Figures & tables
  • Supp info
  • Info & metrics
  • PDF + SI
  • PDF
Loading

ABSTRACT

Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung, localized Fgf10 expression maintains distal Sox9-expressing epithelial progenitors and promotes basal cell differentiation in the cartilaginous airways. Mesenchymal Fgf10 expression is induced by Wnt signaling but inhibited by Shh signaling, and epithelial Fgf10 signaling activates β-catenin signaling. The Hippo pathway is a well-conserved signaling cascade that regulates organ size and stem/progenitor cell behavior. Here, we show that Hippo signaling promotes lineage commitment of lung epithelial progenitors by curbing Fgf10 and β-catenin signaling. Our findings show that both inactivation of the Hippo pathway (nuclear Yap) or ablation of Yap result in increased β-catenin and Fgf10 signaling, suggesting a cytoplasmic role for Yap in epithelial lineage commitment. We further demonstrate redundant and non-redundant functions for the two nuclear effectors of the Hippo pathway, Yap and Taz, during lung development.

Footnotes

  • Competing interests

    The authors declare no competing or financial interests.

  • Author contributions

    Conceptualization: S.P.D.L.; Methodology: S.P.D.L.; Validation: S.P.D.L.; Formal analysis: E.B., S.P.D.L.; Investigation: T.V., T.Y., J.Y., S.H., S.P.D.L.; Resources: S.P.D.L.; Data curation: S.P.D.L.; Writing - original draft: T.V., S.P.D.L.; Writing - review & editing: T.V., T.Y., J.-S.Z., V.J.T., R.F., S.P.D.L.; Visualization: S.P.D.L.; Supervision: S.P.D.L.; Project administration: S.P.D.L.; Funding acquisition: S.P.D.L.

  • Funding

    This study was supported by the National Institutes of Health (R01 HL126732 and HL132156) and by the March of Dimes Foundation (1-FY15-463 to S.P.D.L.). Deposited in PMC for release after 12 months.

  • Supplementary information

    Supplementary information available online at http://dev.biologists.org/lookup/doi/10.1242/dev.166454.supplemental

  • Received August 13, 2018.
  • Accepted December 7, 2018.
http://www.biologists.com/user-licence-1-1/
View Full Text

Log in using your username and password

Forgot your user name or password?

Log in through your institution

You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$30.00 .

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Previous ArticleNext Article
Back to top
Previous ArticleNext Article

This Issue

Keywords

  • Lung
  • Hippo
  • Yap
  • Fgfr2
  • Ilk
  • Fgf10
  • Integrin
  • β-Catenin
  • Differentiation
  • Progenitor

 Download PDF

Email

Thank you for your interest in spreading the word on Development.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling
(Your Name) has sent you a message from Development
(Your Name) thought you would like to see the Development web site.
Share
RESEARCH ARTICLE
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling
Thomas Volckaert, Tingting Yuan, Jie Yuan, Eistine Boateng, Seantel Hopkins, Jin-San Zhang, Victor J. Thannickal, Reinhard Fässler, Stijn P. De Langhe
Development 2019 146: dev166454 doi: 10.1242/dev.166454 Published 16 January 2019
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
RESEARCH ARTICLE
Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling
Thomas Volckaert, Tingting Yuan, Jie Yuan, Eistine Boateng, Seantel Hopkins, Jin-San Zhang, Victor J. Thannickal, Reinhard Fässler, Stijn P. De Langhe
Development 2019 146: dev166454 doi: 10.1242/dev.166454 Published 16 January 2019

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Alerts

Please log in to add an alert for this article.

Sign in to email alerts with your email address

Article navigation

  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • Footnotes
    • References
  • Figures & tables
  • Supp info
  • Info & metrics
  • PDF + SI
  • PDF

Related articles

Cited by...

More in this TOC section

  • The HMG box transcription factors Sox1a and b specify a new class of glycinergic interneurons in the spinal cord of zebrafish embryos
  • ATML1 activity is restricted to the outermost cells of the embryo through post-transcriptional repressions
  • Common cellular origin and diverging developmental programs for different sesamoid bones
Show more RESEARCH ARTICLE

Similar articles

Other journals from The Company of Biologists

Journal of Cell Science

Journal of Experimental Biology

Disease Models & Mechanisms

Biology Open

Advertisement

The people behind the papers – Masanori Kawaguchi, Kota Sugiyama and Yoshiyuki Seki

Yoshiyuki Seki, Kota Sugiyama and Masanori Kawaguchi

Masanori Kawaguchi, Kota Sugiyama and Yoshiyuki Seki at Kwansei Gakuin University in Japan tell us the story behind their research addressing the evolution of pluripotency with an analysis of the function of PRDM14 in zebrafish, amphioxus and sea urchin.


Primer - JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates

Part of Fig. 3: JAK/STAT signaling in homeostasis and regeneration in the Drosophila intestine

Read this Primer by Salvador Herrera and Erika Bach to get an overview of the role of JAK/STAT signaling in stem cells and regeneration in Drosophila testis, intestine and appendages and see the similarities between Drosophila and vertebrates.


Spotlight - Improving the visibility of developmental biology: time for induction and specification

Developmental biology has achieved many amazing accomplishments over the years, but the field needs to consider new strategies for increasing its visibility within the wider scientific community, writes Leonard Zon.


Research Highlight - A deeper look at human retina development

Human eye

Majlinda Lako and colleagues share an integrated transcriptional and immunohistochemical analysis of human retinogenesis in vivo. Read the highlight and the full Human Development article


Call for papers: Chromatin and Epigenetics

Call for papers: Chromatin and Epigenetics

Development is pleased to welcome submissions for an upcoming Special Issue on ‘Chromatin and Epigenetics’, edited by Benoit Bruneau, Haruhiko Koseki, Susan Strome and Maria-Elena Torres-Padilla. This special issue aims to showcase the best research covering the chromatin-based and epigenetic mechanisms which regulate development across the plant and animal kingdoms. Submission deadline: 31 March 2019. 


PreLights – A direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila

PreLighter Natalie Dye

Extensive and dynamic genome binding by a steroid hormone receptor highlights the interconnection between systemic and local cues for organ development, shows a preprint written by Christopher Uyehara and Daniel McKay and highlighted by Natalie Dye.


Articles of interest in our sister journals

The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch
Kelsey F. Sugrue, Anjali A. Sarkar, Linda Leatherbury, Irene E. Zohn
Disease Models & Mechanisms 2019 12: dmm036491

Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans
Yukimasa Shibata, Yoshiyuki Seki, Kiyoji Nishiwaki
Biology Open 2019 8: bio038448

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Special issues
  • Subject collections
  • Sign up for alerts

About us

  • About Development
  • About the Node
  • Editors and board
  • Editor biographies
  • Travelling Fellowships
  • Grants and funding
  • Workshops and Meetings
  • The Company of Biologists

For authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access
  • Biology Open transfer

Journal info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact Development
  • Subscriptions
  • Advertising
  • Feedback

 Twitter   YouTube   LinkedIn

© 2019   The Company of Biologists Ltd   Registered Charity 277992