Embryo geometry drives formation of robust signaling gradients through receptor localization by Zhang et al.

Mind the gap: epiblast geometry at its extraembryonic boundary constrains BMP localization and ensures robust gradient formation.

Selected by Paul Gerald L. Sanchez and Stefano Vianello. Read the preLight here

Ribosomal DNA and the rDNA-binding protein Indra mediate non-random sister chromatid segregation in Drosophila male germline stem cells by Watase and Yamashita

Sisters are not always identical: chromosomal immortality in germline stem cells rests on rDNA loci and their binding partner Indra.

Selected by Maiko Kitaoka. Read the preLight here

Inter-organ growth coordination is mediated by the Xrp1/Dilp8 axis in Drosophila by Boulan et al.

One gene to rule them all: local growth defects caused by impaired ribosomal activity in the fly wing disc trigger systemic growth reduction via Xrp1-mediated activation of Dilp8.

Selected by Alberto Rosello-Diez. Read the preLight here

Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding by Boersma et al.

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Live-cell single RNA imaging reveals bursts of translational frameshifting by Lyon Jr et al.

The secret shifty life of mRNA – evidence for non-stochastic ribosomal frameshifts and out-of-frame translation in cells.

Selected by Nicola Stevenson. Read the preLight here

Suppressor of Fused controls perinatal expansion and quiescence of future dentate adult neural stem cells by Pleasure et al.

What drives establishment of the quiescent neural stem cell pool in the dentate gyrus? The answer lies in the unusual activity of Sufu, a well-known regulator of Shh signalling.

Selected by Ekaterina Dvorianinova. Read the preLight here

The modular mechanism of chromocenter formation in Drosophila by Jagannathan et al.

Not just junk DNA: satellite DNA and their cognate binding proteins form chromocenters to gather up chromosomes in one nucleus.

Selected by Maiko Kitaoka. Read the preLight here

The embryonic transcriptome of Arabidopsis thaliana by Hofmann et al.

Comparison of Arabidopsis embryos to other tissues reveals their distinct and specialized transcriptome.

Selected by Chandra Shekhar Misra. Read the preLight here

An F-actin shell ruptures the nuclear envelope by sorting pore-dense and pore-free membranes in meiosis of starfish oocytes by Wesolowska et al.

Watch out! F-actin spikes push against the nuclear envelope to separate nuclear pores and lead to nuclear envelope breakdown.

Selected by Maiko Kitaoka. Read the preLight here

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Key Regulator Unifying Neurodevelopment and Synaptic Function by Ramos et al.

One DISC to rule them all: DISC1 is a central regulator in a network of proteins involved in neurodevelopment and its disruption could segregate with risk of mental diseases.

Selected by Yasmin Lau. Read the preLight here

A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis by Yoshida et al.

Subcellular signposts – or more? SOSEKI proteins are local outputs of the plant's global coordinate system.

Selected by Martin Balcerowicz. Read the preLight here

RNase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs by Burke et al.

Remodelling the transcriptome after viral infection – a mechanism of RNase L-mediated translational repression revealed.

Selected by Connor Rosen. Read the preLight here

Symmetry breaking in the embryonic skin triggers a directional and sequential front of competence during plumage patterning by Bailleul et al.

Feathers set the bar to study pattern formation: wonderful work combining a unified model and experimental data to recapitulate the complex sequence of events of plumage patterning.

Selected by Alexa Sadier. Read the preLight here

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis by Gumucio et al.

Why do lipids accumulate following muscle injury? A multi-omics study points to mitochondrial and lipid metabolism dysfunction.

Selected by Pablo Ranea Robles. Read the preLight here

The coordination of terminal differentiation and cell cycle exit is mediated through the regulation of chromatin accessibility by Ma et al.

Chromatin accessibility on the wing – insights into chromatin regulation of cell cycle exit.

Selected by Gabriel Aughey. Read the preLight here

Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan by Rougot et al.

Though ezh2-mutant zebrafish form grossly normal body plans, key developmental factors are dysregulated early on, which dooms the embryo to later failure of organogenesis and lethality.

Selected by Yen-Chung Chen. Read the preLight here

Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy by Bevilacqua et al.

How to measure ECM in living organisms with high-resolution but without labels? A new preprint from the Diz-Muñoz and Prevedel labs gives an answer.

Selected by Stephan Daetwyler. Read the preLight here

Unlimited genetic switches for cell-type specific manipulation by Garcia-Marques et al.

CaSSA: a new versatile system for intersectional gene expression enabling cell-type specific manipulations in vivo.

Selected by Rafael Almeida. Read the preLight here