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This issue
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The people behind the papers – Salome Stierli and Alison Lloyd
This work has increased our understanding of the cellular environment of the peripheral nerve
Schwann cells are critical to peripheral nerve regeneration following injury but whether an additional stem cell or progenitor population also contributes has been a matter of contention. This paper addresses that issue with a characterisation of Schwann cell behaviour in the homeostatic and regenerating mouse peripheral nerve. First author Salome Stierli and her supervisor Alison Lloyd from University College London tell us more about their work.
Huili Li, Jing Zhang and Lee Niswander identify p53 stabilization and p53-mediated cell death as crucial mechanisms underlying zinc deficiency-induced neural tube defects.
Eric Olson and colleagues discuss the roles of transcription factors, histone modifications and chromatin organization during heart development and repair, highlighting common mechanisms and possible strategies for targeted regeneration in their Review.
Annabel Adams preparing tissues for fluorescent imaging.
The Gurdon/The Company of Biologists Summer Studentship scheme provides financial support to ten highly motivated undergraduate students each year, to allow them an opportunity to engage in practical research at a research lab during their summer vacation. This year their research choices included craniofacial defects under maternal diabetes, fruiting body formation in Dictyostelium, micropthalmia, cerebellar development and more. Read their reports here.
Development is pleased to welcome submissions for an upcoming Special Issue on ‘Chromatin and Epigenetics’, edited by Benoit Bruneau, Haruhiko Koseki, Susan Strome and Maria-Elena Torres-Padilla. This special issue aims to showcase the best research covering the chromatin-based and epigenetic mechanisms which regulate development across the plant and animal kingdoms. Submission deadline: 31 March 2019.
preLights - Embryo geometry drives formation of robust signaling gradients through receptor localization
Gerald L. Sanchez and Stefano Vianello highlight a preprint showing the importance of restricted receptor localization in a mouse embryo, and consequently the embryo’s geometry, in the establishment of a robust signalling gradient of a morphogen.
Catch up with recent preLights selected for the developmental biology community.
Articles of interest in our sister journals
Identifying mouse developmental essential genes using machine learning
David Tian, Stephanie Wenlock, Mitra Kabir, George Tzotzos, Andrew J. Doig, Kathryn E. Hentges
Disease Models & Mechanisms 2018 11: dmm034546
Direct binding of Talin to Rap1 is required for cell–ECM adhesion in Drosophila
Darius Camp, Amanda Haage, Veronika Solianova, William M. Castle, Qinyuan A. Xu, Emily Lostchuck, Benjamin T. Goult, Guy Tanentzapf
J Cell Sci 2018 131: jcs225144