In this Editorial, James Briscoe and Katherine Brown take stock of the ever-evolving scope of Development, which reflects changes in the field and future priorities for the journal.

Gabriel Aughey, Seth Cheetham and Tony Southall provide an overview of DNA adenine methyltransferase identification (DamID), which is used to profile genome-wide chromatin interactions, and introduce recent improvements to the technology.

Emerging evidence on the phenomenon of non-DNA sequence-based inheritance in multiple species, including mammals, urges a rethinking of the nature of hereditary information carriers and the ways in which they encode heritable traits, write Ying Zhang and Qi Chen.

Kyle Harrington, Jan Huisken and team present a novel dedicated multi-sample light sheet imaging, processing and analysis platform and demonstrate its value in diverse quantitative long-term imaging studies, such as vascular growth in zebrafish, as shown in this movie.

Call for papers: Chromatin and Epigenetics