Drosophila larval central nervous system comprises the central brain, ventral nerve cord and optic lobe. In these regions, neuroblasts divide asymmetrically to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation is still unclear, especially in the optic lobe. Here we show that the zinc finger transcription factor Nerfin-1 is expressed in early stage of medulla neurons and essential for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation.
- Received June 21, 2016.
- Accepted February 17, 2017.
Other journals from The Company of Biologists
Special Issue: On Growth and Form - 100 years on
To mark the centenary of the publication of D’Arcy Thompson’s On Growth and Form, Development is planning a special issue titled ‘On Growth and Form - 100 years on’. This issue will focus on physical and mathematical approaches to understanding developmental processes. We invite you to submit your breakthrough research for consideration in this special issue coordinated by Guest Editor L. Mahadevan (Harvard University) and our Editor Thomas Lecuit.
Currently on the Node: the people behind the papers
In an interview on the Node, Holly Voges, and her co-supervisors Enzo Porrello and James Hudson from the Cardiac Regeneration Lab at the University of Queensland tell the stories behind their cardiac regeneration research. Their paper on use of human cardiac organoids to address the regenerative capacity of the immature heart is part of the current Development special issue on organoids.
Travelling Fellowships: expanding perspectives
Ngang Heok Tang used a Travelling Fellowship from Development to travel to Dr Fumio Motegi’s lab in Singapore. There, he learned a range of new techniques to advance his research into the role of EFA-6 in C.elegans axon regrowth. Presenting his work to other worm researchers also helped Ngang Heok gain new perspectives on his project. Read more on his story here.
Where could your research take you?
Join Ngang Heok and the 20 early career scientists who were awarded Travelling Fellowships from Development in 2016. Apply now!
Transfer to Biology Open
If your submission to Development is unsuccessful, did you know you can transfer your paper and any reviews directly to our sister journal, Biology Open? The majority of papers transferred with reviews are accepted for publication. Find out how here.