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About the Cover
Defects in corticofugal axon growth in the Pax6-/- brain revealed by tracing with carbocyanine dyes from the dorsal cerebral cortex at E18.5. The corticofugal axons were labelled with DiI (orange-red) and the tissue was counterstained with bizbenzimide (blue). The fluorescent photomicrograph was taken using double exposure with two different filters from a coronal section through the left hemisphere of a Pax6-/- brain. The image demonstrates that in the mutant brain, most of the corticofugal axons bundle up into large fascicles and fail to turn into the primitive internal capsule. They continue to descend through the intermediate zone and cross the pallial-subpallial boundary at a more-ventral position and in larger fascicles, than seen in controls. For further details, see article by L. Jones, G. López-Bendito, P. Gruss, A. Stoykova and Z. Molnár, in this issue Development 129, 5041-5052.
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