Table 1.

Cystic kidney genes identified in the screen

GenesMutantsKidney cystCurved bodyLinkage analysis
Group I mutants
   vhnf1 hi548
hi2169 +-Golling et al., 2002; Sun and Hopkins, 2001
   cad1/caudal hi2092, hi2188A hi2617 +-24/24 mutant; 0/24 wild type for 2188A (Golling et al., 2002)
Group II mutants
   IFT57 hi3417/curly ++16/16 mutant; 0/46 wild type
   IFT81 hi409/larry ++90/90 mutant; 0/36 wild type
   IFT172 hi2211/moe ++137/137 mutant; 0/55 wild type
   scorpion hi459/scorpion ++64/64 mutant; 0/102 wild type (Golling et al., 2002)
   pontin hi1055B ++45/45 mutant; 0/50 wild type
   seahorse hi3308/seahorse ++43/43 mutant; 0/50 wild type
   qilin hi3959A/qilin ++58/58 mutant; 0/87 wild type
   pkd2 hi4166 morphant ++99/99 mutant; 0/93 wild type
   not cloned hi1392/twister ++69/69 mutant; 0/90 wild type
   not cloned hi2005/enigma ++63/63 mutant; 0/64 wild type
  • The three IFT mutants were named larry, moe and curly. The mutants with mutations in novel genes were named scorpion, seahorse and qilin (a Chinese mythical creature similar to unicorn). The remaining two uncloned mutants were named enigma and twister. In linkage analysis, numbers show out of analyzed mutant and wild-type embryos, how many are found to be homozygous for the corresponding proviral insertion. For some mutants, the linkage data has been reported in the supplemental data of our previous publication (Golling et al., 2002; Sun and Hopkins, 2001).