Table 1.

Atrial septal dysmorphogenesis in adult mice

GenotypenNormal (%)PFO (%)ASA (%)PFO + ASA (%)ASD (%)
Wild type2118 (85.7)3 (14.3)0 (0)0 (0)0 (0)
Tbx20lacZ/+ 209 (45)6 (30)1 (5)4 (20)0 (0)
Nkx2-5GFP/+ 242 (8.3)12 (50)1 (4.2)9 (37.5)0 (0)
Tbx20lacZ/+/Nkx2-5GFP/+ 243 (12.5)4 (16.6)1 (4.2)12 (50)*4 (16.7)
  • PFO, patent foramen ovale; ASA, atrial septal aneurysm; ASD, atrial septal defect.

  • * Increase compared with PFO+ASA in Nkx2-5GFP/+ not significant

  • P<0.05 compared with all other genotypes