Table 1.

Components of a Notch signalling cascade are required during dauer development

GenotypeDauer recovery*
daf-7(e 1372) 5.3±0.27 (539)
daf-7(m70) 22.5±1.52 (200)
daf-7(e1372); lag-2(q420) 81.3±6.43 (416)
lin-12(n696n927) dat-7(e1372) 0 (150)
lin-12(n696n930) daf-7(e1372) 0 (150)
lin-12d(n302gf) daf-7(e1372) 21.7±1.90 (410)
lin 12d(n950gf) daf-7(e1372) 61.5±4.54 (302)
glp-1(e2141) daf-7(e1372) 84.7±3.61 (354)
glp-1(q231) daf-7(e1372) 37.7±2.1 (450)
glp-1(e2141) daf-7(m70) 73.0±6.52 (137)
daf-7(e1372); lag-1 (om13) 0.42±0.12 (416)
glp-1 (e2141) daf-7(e1372); lag-1(om13) 0 (186)
daf-7(m70); lag-1(om13) 13.1±2.15 (130)
ins-18(tm339); daf-7(e1372) 28.7±1.2 (150)
ins-18(tm339); daf-7(e1372); ins-18::ins-18 1.0±0.3 (100)§
  • * Results are expressed as the percentage of animals ±s.d. that recover from dauer at 25°C 24 hours after transfer. The total number of dauer larvae scored (n) is indicated in parentheses. Statistical analyses were performed using a Student's t-test: P<0.005, compared with the indicated genotypes.

  • daf-7(e1372).

  • daf-7(m70).

  • glp-1(e2141) daf-7(e1372).

  • § ins-18(tm339); daf-7(e1372).