- IKKε inhibits PKC to promote Fascin-dependent actin bundling
Summary: The protein kinase IKKϵ is active at the growing tip of Drosophila bristles and prevents excess PKC activation during bristle actin bundle organization and morphogenesis.
- Crucial roles of the Arp2/3 complex during mammalian corticogenesis
Summary: During mouse cortical development, the Arp2/3 actin branching complex regulates process formation and the maintenance of radial glial cell polarity, as well as affecting neuronal migration.
- Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
Summary: The kinase Src64 controls tyrosine phosphorylation and actin dynamics to mediate proper ring canal formation during incomplete cytokinesis, which is required for Drosophila germline cyst development in vivo.
- Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis
Highlighted article: In the early zebrafish embryo, dcsh1b and dcsh2 organize actin and microtubule networks, sometimes independently of their known ligand Fat, to control several aspects of embryogenesis.
- The Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton
Summary: The gene mwh, which acts downstream in the Drosophila PCP pathway, directly acts on the cytoskeleton to ensure that each wing cell produces a single distally pointing hair.
- Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum
Highlighted article: Cellularization in the embryo of the beetle Tribolium requires the junction protein Innexin7a, which links the basal membrane to the yolk membrane. This mechanism is distinct from that in Drosophila.
- Live imaging of endogenous protein dynamics in zebrafish using chromobodies
SUMMARY: Chromobodies - small, intracellular fluorescent antibodies - are used to trace endogenous antigens, without the need for direct protein tagging, in zebrafish embryos.
- Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains
Highlighted article: In the neuroepithelium, apical cofilin 1 activates actomyosin contractility to promote neural tube closure, while basally it prevents ectopic myosin activation and tight junction formation.
- Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea
Summary: A subset of cilia proteins are involved in intracellular trafficking of membrane-bound proteins, including planar cell polarity regulators, to non-ciliary locations.
- Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity
Summary: Planar polarity in Arabidopsis is shaped by ACTIN-INTERACTING PROTEIN1-2, which is under the control of WEREWOLF-dependent patterning and ethylene signalling.