- Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis
Summary: Genetic analyses of Esama function in mutant zebrafish embryos reveal specific and redundant functions of Esama and VE-cadherin proteins in endothelial cell recognition and blood vessel morphogenesis.
- Blood vessel anastomosis is spatially regulated by Flt1 during angiogenesis
Summary: During mammalian blood vessel formation in vivo and in vitro, Flt1 regulates both the frequency of transient contacts that occur before vessels form stable connections and target site selectivity.
- Vegfa signals through ERK to promote angiogenesis, but not artery differentiation
Summary: ERK acts as a specific effector of Vegfa signaling to induce angiogenic genes during vascular sprouting in zebrafish.
- cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner
Summary: During zebrafish angiogenesis, endothelial PKA activity regulates the transition from sprouting to stabilisation of nascent vessels, preventing excessive tip cell formation and hypersprouting.
- Slit-Robo signaling
Summary: This Development at a Glance article summarizes new insights into Slit-Robo evolutionary and system-dependent diversity, receptor-ligand interactions, signaling crosstalk and receptor activation.
- Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis
Highlighted Article: Apoptosis is a consequence of vessel regression, not a cause, and serves to modulate endothelial cell numbers, remove non-perfused vessels and regulate capillary calibre during retinal development in mice.
- Blood vessel formation and function in bone
Summary: This Review discusses the roles of blood vessels in controlling developmental and regenerative bone formation and providing niche microenvironments for various cell types.
- Alk1 controls arterial endothelial cell migration in lumenized vessels
Summary: Cell tracking in a zebrafish model of hereditary hemorrhagic telangiectasia reveals that the primary defect leading to arteriovenous malformations is misdirected EC migration within lumenized arteries.
- Cell behaviors and dynamics during angiogenesis
Summary: This Review discusses endothelial cell behavior during developmental angiogenesis, focusing on the morphogenetic changes that these cells undergo.
- Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells
Summary: Endothelial cells produce Sema3A, a known axon repellent, that exerts repelling functions on VEGF-A-induced tip cell filopodia during angiogenesis in mice.