- Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs
Summary: Genome-wide analysis of Wnt and BMP targets in the Xenopus gut endoderm reveals cooperation and crosstalk between these pathways through integration of Smad1 and β-catenin on cis-regulatory elements.
- Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2
Summary: Osteoblast specification requires regulatory inputs from BMP2 at the Runx2/Osx1 transition by a mechanism that is not compensated for by canonical Wnt signaling and involves Grhl3.
- Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner
Summary: Forced activation of Wnt signaling in the sensory domain of the developing cochlea impacts radial patterning and downstream gene expression in a spatiotemporal manner.
- Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos
Summary: Tril is a Gata2 target gene that triggers degradation of Smad7 protein during gastrulation, allowing for robust transduction of Bmp signals to enable the commitment of mesoderm to a blood fate.
- Ror2 signaling is required for local upregulation of GDF6 and activation of BMP signaling at the neural plate border
Summary: The Wnt receptor Ror2 links planar cell polarity and cell movements during gastrulation via the upregulation of BMP signaling at the neural plate border and subsequent induction of the neural crest.
- Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
Summary: In the vertebrate eye, dorsally expressed Gdf6a limits RA pathway activity to control the transition from proliferation to differentiation, thereby regulating eye size.
- Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis
Summary: A zebrafish maternal-effect mutant split top reveals a novel function for the lysosomal endopeptidase cathepsin B in dorsoventral axial patterning and early embryonic morphogenesis.
- The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis
Summary: This Review article presents a comprehensive view of the endocardium: how it develops and then functions as an important angiocrine signalling centre, sensor and transducer of biophysical forces.
- Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse
Summary: The genetic deletion of Bmpr1a in mice reveals a dual function for BMP signaling in restricting preosteoblast proliferation and promoting osteoblast activity, probably via regulation of mTORC1.
- Next generation limb development and evolution: old questions, new perspectives
Summary: This Review discusses novel insights into the gene regulatory networks that govern limb development, fin-to-limb transition and digit reductions during tetrapod limb evolution.