- Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids
Summary: In human cerebral organoids, depletion of the tumor suppressor retinoblastoma protein disrupts proliferation, promotes entry into S-phase, and causes increased apoptosis and aberrant neuronal migration.
- Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming
Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.
- sequoia controls the type I>0 daughter proliferation switch in the developing Drosophila nervous system
Summary: During Drosophila embryonic CNS development, the zinc-finger protein Sequoia interacts with the Notch pathway to control lineage progression.
- Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo
Highlighted article: CYB-3 cyclin controls both mitotic entry and S-phase entry in the one-cell embryo, while variations in the level of CYB-3 at the two-cell stage regulates asynchronous cell cycling.
- Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning
Summary: In the fly notum, a reciprocal relationship between Notch signalling and cell cycle progression acts like a clock, providing a delimited window of time during which cells decide their fate.
- Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication
Summary: S phase-coupled destruction of the Drosophila CDK inhibitor Dacapo mediates oscillations of Dap protein accumulation and may help to regulate endocycle frequency and polyploidization during development.
- Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila
Summary: Protein phosphatase 2A controls cell cycle progression in the developing Drosophila eye and wing - inhibiting Cdk2/Cyclin E to induce the quiescent state.
- Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage
Highlighted article: The Hippo pathway transcriptional effectors Scalloped and Yorkie are required to drive quiescent cells into the cell cycle in response to tissue damage in the developing Drosophila eye.
- Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression
Summary: The transcription factor Hbp1 regulates neural development in mouse: upon Hbp1 depletion, progenitor cell cycle length shortens due to derepression of cyclin D1, and neuronal differentiation is also impaired.