- PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis
Summary: Analysis of PDGFRα gain-of-function mutant mice demonstrates a role in balancing the expansion of fibroblast and adipocyte lineages before birth.
- Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming
Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.
- Blood stem cells: from beginning to end
Summary: This report highlights the major themes and advances presented at the recent EMBL conference 'Hematopoietic stem cells: from the embryo to the aging organism'.
- SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary
Summary: SOX2 has two independent roles during pituitary morphogenesis: promoting progenitor proliferation via SIX6 and determining melanotroph identity via PAX7.
- The insulator protein BEAF-32 is required for Hippo pathway activity in the terminal differentiation of neuronal subtypes
Summary: During cell fate specification in the Drosophila eye, BEAF-32 regulates expression of Hippo pathway components and acts downstream of Warts to control photoreceptor identity.
- The regulation and plasticity of root hair patterning and morphogenesis
Summary: This Review discusses how the complex interplay of intrinsic programs and external cues shapes the form and function of root hair cells in plants.
- The transcription factor Glass links eye field specification with photoreceptor differentiation in Drosophila
Summary: The transcription factor Glass functions downstream of Sine oculis to activate the expression of phototransduction proteins via its direct target, Hazy.
- Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis
Highlighted article: In the early zebrafish embryo, dcsh1b and dcsh2 organize actin and microtubule networks, sometimes independently of their known ligand Fat, to control several aspects of embryogenesis.
- A common Shox2–Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
Summary: Antagonism between Shox2 and Nkx2-5 in the cardiac venous pole of mouse embryos regulates cell fate, morphogenesis and the distinction between pacemaker cells and working myocardium.