- Prostate organogenesis: tissue induction, hormonal regulation and cell type specification
Summary: This Review article provides a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.
- Using synthetic biology to explore principles of development
Summary: This Review highlights how synthetic biology-based approaches have been used to explore the principles underlying patterning, differentiation and morphogenesis during development.
- Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality
Summary: A broad repertoire of conventional human ESCs and transgene-independent iPSC lines can be reverted to stable naive states using WNT, MEK/ERK and tankyrase inhibition.
- DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary.
- Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway
Summary: Loss of filamin and formin causes multiple developmental defects, highlighting roles for these two proteins in Wnt signaling, Lrp6 endocytosis, Gsk3 activation and target gene expression.
- Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming
Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.
- Reversible optogenetic control of kinase activity during differentiation and embryonic development
Summary: Light is used to modulate the timing of mitogen-activated protein kinase activity during PC12 cell differentiation and distinct developmental stages of Xenopus embryos.
- Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling
Summary: Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, regulates morphogenesis, differentiation and cell survival of the duodenum, by modulating expression of Notch pathway ligands.
- A role for post-transcriptional control of endoplasmic reticulum dynamics and function in C. elegans germline stem cell maintenance
Summary: PUF-8 promotes germline stem cell proliferation by promoting the expression of FARL-11, an ER protein that facilitates the membrane localization of GLP-1 /Notch.
- ATP-dependent chromatin remodeling during mammalian development
Summary: This Review summarizes the mechanisms by which chromatin remodelers function and highlights their specificities during mammalian cell differentiation and organogenesis.