- Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway
Summary: Loss of filamin and formin causes multiple developmental defects, highlighting roles for these two proteins in Wnt signaling, Lrp6 endocytosis, Gsk3 activation and target gene expression.
- Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming
Summary: This Review article discusses how cell fate decisions in development are linked to the cell cycle, and the key molecular components thereof.
- DNA damage-induced Lok/CHK2 activation compromises germline stem cell self-renewal and lineage differentiation
Highlighted article: DNA damage disrupts stem cell self-renewal and differentiation in a CHK2 kinase-dependent manner, which may be due to reduced BMP signaling and cell adhesion in the Drosophila ovary.
- Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality
Summary: A broad repertoire of conventional human ESCs and transgene-independent iPSC lines can be reverted to stable naive states using WNT, MEK/ERK and tankyrase inhibition.
- Reversible optogenetic control of kinase activity during differentiation and embryonic development
Summary: Light is used to modulate the timing of mitogen-activated protein kinase activity during PC12 cell differentiation and distinct developmental stages of Xenopus embryos.
- Brg1 plays an essential role in development and homeostasis of the duodenum through regulation of Notch signaling
Summary: Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, regulates morphogenesis, differentiation and cell survival of the duodenum, by modulating expression of Notch pathway ligands.
- A role for post-transcriptional control of endoplasmic reticulum dynamics and function in C. elegans germline stem cell maintenance
Summary: PUF-8 promotes germline stem cell proliferation by promoting the expression of FARL-11, an ER protein that facilitates the membrane localization of GLP-1 /Notch.
- ATP-dependent chromatin remodeling during mammalian development
Summary: This Review summarizes the mechanisms by which chromatin remodelers function and highlights their specificities during mammalian cell differentiation and organogenesis.
- Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes
Summary: A large-scale RNAi screen in Drosophila testes reveals that many genes involved in protein synthesis and degradation are required for the homeostasis of germline stem cells and their niches.
- Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals
Summary: During mouse retinogenesis, the Sip1 transcription factor participates in the gene regulatory network that controls timely cell cycle exit and differentiation of a subset of retinal progenitor cells.