- Phosphorylation potential of Drosophila E-Cadherin intracellular domain is essential for development and adherens junction biosynthetic dynamics regulation
Summary: Phosphorylations of the conserved serine cluster in the Drosophila E-Cadherin intracellular tail are quantitatively rather than site specifically required for its function in adherens junction formation.
- Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscle in vivo
Summary: In Drosophila, immature myofibrils are built simultaneously across an entire muscle fiber, and then self-organize in a manner dependent on spontaneous contractions and mechanical tension.
- Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion
Summary: PI3-kinase-dependent regulation of DE-cadherin controls cell adhesion between Drosophila neuroblasts and neighboring cortex glia, and between neuroblasts and their daughter cells.
- Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torso-like in receptor activation
Summary: Evenly distributed Trunk protein and terminally localized Torso-like combine to promote spatially restricted dimerization and activation of the receptor tyrosine kinase Torso.
- Remodeling of adhesion and modulation of mechanical tensile forces during apoptosis in Drosophila epithelium
Summary: The transient release of tension upon a reduction in the levels of adherens junctions components contributes to apoptotic cell extrusion in Drosophila epithelium.
- The Drosophila Hox gene Ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections
Summary: Ultrabithorax controls correct innervation of ventrolateral muscles by coordinating Wnt4 ligand expression in muscles with the signalling pathway response in motoneurons.
- Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche
Summary: In the Drosophila ovary, the Six4 and Groucho proteins link the activities of the Notch and EGFR pathways to regulate the earliest cell fate decision in the follicle stem cell lineage.
- Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues
Summary: Elav – the canonical Drosophila marker for post-mitotic neurons – has a previously unrecognized component of ubiquitous expression that is suppressed by the microRNA pathway, including by miR-279/996.
- A new mode of mitochondrial transport and polarized sorting regulated by Dynein, Milton and Miro
Summary: Bi-directional mitochondrial transport driven by Dynein is regulated by Milton at primary anterograde sorting, whereas Miro regulates a retrograde transport switch.