- Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis
Summary: Genetic analyses of Esama function in mutant zebrafish embryos reveal specific and redundant functions of Esama and VE-cadherin proteins in endothelial cell recognition and blood vessel morphogenesis.
- Endothelial cell regulation of salivary gland epithelial patterning
Summary: In an ex vivo gland reconstitution model, perfusion-independent signaling by CD31+ endothelial cells opposes the emergence of K19+/K7+ cells in the endbuds of early developing submandibular salivary glands.
- Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology
Highlighted article: Collagen I is deposited by osteoblasts onto endothelial cells within bone and serves as a template for mineralisation, with ossification thus spatially and temporally following vascular patterning.
- Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis
Highlighted Article: Apoptosis is a consequence of vessel regression, not a cause, and serves to modulate endothelial cell numbers, remove non-perfused vessels and regulate capillary calibre during retinal development in mice.
- Blood vessel formation and function in bone
Summary: This Review discusses the roles of blood vessels in controlling developmental and regenerative bone formation and providing niche microenvironments for various cell types.
- Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain
Summary: Neuropilin 1 and β8 integrin cooperatively promote cerebral angiogenesis by mediating adhesion and signaling events between neuroepithelial cells and vascular endothelial cells in the mouse brain.