- FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition
Summary: FGF signaling is required for post-gastrula paraxial mesoderm induction through a unique mechanism that differs from its role during gastrula stage mesoderm induction.
- Nodal and FGF coordinate ascidian neural tube morphogenesis
Summary: Live imaging of neural tube morphogenesis in Ciona uncovers roles for FGF and Nodal signaling in controlling the intercalation and stacking behaviors of cells.
- Control of lens development by Lhx2-regulated neuroretinal FGFs
Summary: The LIM homeodomain transcription factor Lhx2 regulates FGF3, FGF9 and FGF15 and is essential for lens cell proliferation, survival and differentiation in mice.
- Regulation of self-renewing neural progenitors by FGF/ERK signaling controls formation of the inferior colliculus
Summary: FGF/ERK signaling controls the formation of the mouse inferior colliculus by maintaining a neural progenitor zone and by regulating cell survival, polarity and specification.
- Fgf signalling controls diverse aspects of fin regeneration
Summary: During fin regeneration in zebrafish, Fgf20a signals from the wound epidermis to induce blastema formation while blastema Fgfs, including Fgf3, subsequently support cell proliferation.
- Re-epithelialization of cutaneous wounds in adult zebrafish combines mechanisms of wound closure in embryonic and adult mammals
Summary: Chemical treatments combined with live imaging reveal that re-epithelialization of zebrafish wounds utilizes TGFβ/integrin-dependent active keratinocyte crawling as well as epidermal rearrangements.
- Neurogenesis in sea urchin embryos and the diversity of deuterostome neurogenic mechanisms
Summary: The process of neurogenesis in sea urchins shares features with chordate neurogenesis but is distinct from that seen in other ambulacraria, highlighting that deuterostomes employ diverse neurogenic mechanisms.
- Next generation limb development and evolution: old questions, new perspectives
Summary: This Review discusses novel insights into the gene regulatory networks that govern limb development, fin-to-limb transition and digit reductions during tetrapod limb evolution.
- Neuromesodermal progenitors and the making of the spinal cord
Summary: This Hypothesis considers the growing evidence for a dual origin of the central nervous system: as well as the neuroectoderm lineage, neuromesodermal progenitors contribute to the spinal cord.
- Tissue-specific roles of Fgfr2 in development of the external genitalia
Summary: The development of mouse urethral tube is a sexually dimorphic process that requires Fgfr2-mediated cell cycle progression and epithelial maturation in distinct tissue compartments.