- In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development
Summary: Human embryonic stem cell-derived intestinal organoids can be patterned into duodenum-like or ileum-like tissue, recapitulating in vivo human development.
- Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion
- Genetic redundancy of GATA factors in the extraembryonic trophoblast lineage ensures the progression of preimplantation and postimplantation mammalian development
Summary: During trophoblast development in mice, GATA2 and GATA3 act synergistically by directly regulating a large number of common genes, and together are important to ensure trophoblast lineage progression.
- From stem cells to human development: a distinctly human perspective on early embryology, cellular differentiation and translational research
Summary: This Meeting Review summarises the major themes and results presented at the second 'From Stem Cells to Human Development' meeting, held in October 2016.
- Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling
- Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate
- Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors
Summary: Bmi1 is required to prevent postnatal degeneration of cone photoreceptors and bipolar neurons, while BMI1 inactivation in human embryonic stem cells impairs cone terminal differentiation.
- The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis
Highlighted article: The developmental transcription factor SOX6 is a positive regulator of adipogenesis in vertebrates and is associated with the fetal origins of human obesity.
- WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate
Highlighted article: A new protocol for human neural crest induction from hESCs is fast and efficient, and involves TGFβ, FGF and BMP signaling to specify the neural crest independent of neural ectoderm and mesoderm.
- OCT4 activity during conversion of human intermediately reprogrammed stem cells to iPSCs through mesenchymal-epithelial transition
Highlighted article: The generation of a stable human intermediately reprogrammed stem cell line reveals differences in the mechanisms of reprogramming between mouse and human.