- Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues
Summary: Proper differentiation of somatic cyst stem cells as they move away from their niche requires an increase in PI3K/Tor signaling, downstream of Insulin receptor activation.
- glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
HIGHLIGHTED ARTICLE: Peptides derived from the glucagon gene are necessary for α to β cell fate switching during pancreatic islet regeneration in zebrafish.
- Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis
Summary: Inactivation of the Bicc1 gene, which is associated with kidney displasia in humans, causes pancreatic endocrine differentiation defects leading to cyst formation.