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iPSC

  • STEM CELLS AND REGENERATION
    Single-cell mechanical phenotype is an intrinsic marker of reprogramming and differentiation along the mouse neural lineage
    Marta Urbanska, Maria Winzi, Katrin Neumann, Shada Abuhattum, Philipp Rosendahl, Paul Müller, Anna Taubenberger, Konstantinos Anastassiadis, Jochen Guck
    Development 2017 144: 4313-4321; doi: 10.1242/dev.155218

    Summary: Stiffening accompanies reprogramming of murine fetal neural progenitor cells towards pluripotency and is reversed in neural differentiation of pluripotent cells.

  • SPOTLIGHT
    Using brain organoids to understand Zika virus-induced microcephaly
    Xuyu Qian, Ha Nam Nguyen, Fadi Jacob, Hongjun Song, Guo-li Ming
    Development 2017 144: 952-957; doi: 10.1242/dev.140707

    Summary: This Spotlight article summarises the latest advances in using cerebral organoids to model Zika virus infection and the resulting pathology.

  • REVIEW
    A developmental framework for induced pluripotency
    Kazutoshi Takahashi, Shinya Yamanaka
    Development 2015 142: 3274-3285; doi: 10.1242/dev.114249

    Summary: This Review explores the differences and similarities between the biological processes driving developmental cell differentiation and those mediating cell reprogramming.

  • TECHNIQUES AND RESOURCES
    Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells
    Hideki Masaki, Megumi Kato-Itoh, Ayumi Umino, Hideyuki Sato, Sanae Hamanaka, Toshihiro Kobayashi, Tomoyuki Yamaguchi, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Hiromitsu Nakauchi
    Development 2015 142: 3222-3230; doi: 10.1242/dev.124016

    Summary: An approach to assess the chimera-forming ability of PSCs is developed and used to assess the developmental potential of rodent, monkey and human PSCs.

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