- Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development
Summary: VEGFD has been considered dispensable for vascular development in vertebrates. Its mutation reveals that Vegfd plays context-specific and compensatory roles during both angiogenesis and lymphangiogenesis.
- Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors
Summary: Genome-editing approaches in zebrafish reveal that distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations.
- Development of the lymphatic system: new questions and paradigms
Summary: This Review discusses the molecular mechanisms controlling lymphatic system development and highlights findings that shed light on previously uncharacterised sources of lymphatic endothelial cells.