- A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes
Summary: MAPK-mediated phosphorylation and degradation of CPEB1 triggers meiotic cell cycle-coupled translation of dormant maternal mRNAs during oocyte maturation and maternal-zygotic transition.
- CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes
Summary: CenpH, a component of the kinetochore inner plate protein, is necessary for cyclin B1 stabilization and is responsible for the G2/M transition in meiotic mouse oocytes.
- Widespread failure to complete meiosis does not impair fecundity in parthenogenetic whiptail lizards
Summary: The fecundity of unisexual whiptail lizards is similar to bisexual relatives despite pseudo-tetraploid oocytes being exceedingly rare and diploid oocytes failing to proceed past the pairing stage of meiosis.
- Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly
Summary: In C. elegans, the MEI-2 subunit of Katanin is required for its microtubule-severing activity. Katanin variants that can bind but not sever microtubules can not support normal meiotic spindle assembly.
- The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos
Highlighted article: The H3K9 methyltransferase Setdb1 is required during mouse oogenesis to control gene expression, restrain expression of endogenous retroviruses and enable successful progression through meiosis and mitosis.
- Drosophila dany is essential for transcriptional control and nuclear architecture in spermatocytes
Summary: The nuclear protein Dany associates with euchromatic regions in Drosophila spermatocytes, controls the spermatocyte gene expression program, and regulates chromatin-nuclear envelope interactions.
- Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis
Summary: Novel roles are uncovered for centromere assembly factors CENP-C and CAL1 in meiotic chromosome segregation, CENP-A assembly and maintenance of sperm, as well as fertility in Drosophila males.
- Escape of X-linked miRNA genes from meiotic sex chromosome inactivation
Summary: During mouse spermatogenesis, some miRNA genes escape pan-chromosomal silencing of the X, in a process involving their physical relocation away from the XY body heterochromatin domain.
- Cell type-specific translational repression of Cyclin B during meiosis in males
Summary: The translation timing of Cyclin B1 RNA during meiotic prophase in the male Drosophila germline is regulated by two interacting proteins, Rbp4 and Fest.