- The physics of organoids: a biophysical approach to understanding organogenesis
Summary: This Spotlight article discusses some interesting applications of physics in organoid research, from computational modeling of organoid biology to understanding mechanical aspects of organ development.
- Modeling halotropism: a key role for root tip architecture and reflux loop remodeling in redistributing auxin
Summary: During halotropism, root tip architecture allows for a decrease in PIN2 at the salt-exposed side of the root, resulting in re-routing of auxin to the opposite side; feedback on AUX1 amplifies this auxin asymmetry.
- Expression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication
Summary: S phase-coupled destruction of the Drosophila CDK inhibitor Dacapo mediates oscillations of Dap protein accumulation and may help to regulate endocycle frequency and polyploidization during development.
- Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle
Summary: A three dimensional in silico model of C. elegans predicts that adult germ cells are subject to a mechanical feedback on the cell cycle akin to contact inhibition.