- Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscle in vivo
Summary: In Drosophila, immature myofibrils are built simultaneously across an entire muscle fiber, and then self-organize in a manner dependent on spontaneous contractions and mechanical tension.
- Dach2-Hdac9 signaling regulates reinnervation of muscle endplates
Summary: Dach2 and Hdac9 work in a collaborative fashion to inhibit the reinnervation of denervated mouse skeletal muscle by suppressing the denervation-dependent expression of Myog and Gdf5.
- A non-signaling role of Robo2 in tendons is essential for Slit processing and muscle patterning
Summary: Robo2 is required in tendons to restrict Slit distribution by promoting its cleavage into a non-diffusible Slit-N, affecting muscle elongation towards tendons in Drosophila embryos.
- Slit cleavage is essential for producing an active, stable, non-diffusible short-range signal that guides muscle migration
HIGHLIGHTED ARTICLE: The muscle-repelling, secreted protein Slit is cleaved into a stable, membrane-tethered protein that acts as a short-range stop signal for migrating Drosophila muscle cells.
- Drosophila small heat shock protein CryAB ensures structural integrity of developing muscles, and proper muscle and heart performance
Summary: dCryAB, a heat shock protein, displays stress-independent expression in Drosophila muscles and interacts with the actin crosslinker filamin to ensure proper muscle cytoarchitecture.
- Muscle composition is regulated by a Lox-TGFβ feedback loop
Summary: Lysyl oxidase, an enzyme that regulates extracellular matrix organization, attenuates TGFß signaling to control the balance of myofibres and connective tissue in muscle.